Anti-GPCR GPR78 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

GPR78 functions within the nervous system where it contributes to neurodevelopmental processes and synaptic signaling. Researchers have not yet identified specific ligands classifying it as an orphan receptor. Studies indicate GPR78's involvement in forming signaling complexes involving other membrane proteins allowing it to influence synaptic plasticity and neuron communication. This aligns with its expression in the brain hinting at its role in central nervous system activities.

Pathways

GPR78's function integrates into critical signaling cascades in the brain. It is associated with the cAMP signaling pathway which is important in neurotransmitter release and neuronal communication. The presence of GPR78 in this pathway suggests interactions with proteins like adenylyl cyclase influencing downstream signaling events. Additionally GPR78 might interact with proteins involved in the Wnt signaling pathway a fundamental process in brain development and synapse formation.