Anti-GPCR GPR85 antibody - C-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The GPCR GPR85 also known as Super Conserved Receptor Expressed in the Brain 2 (SREB2) is a G-protein coupled receptor. It weighs approximately 43 kilodaltons. GPR85 is mostly expressed in the central nervous system especially in areas such as the cerebral cortex and hippocampus. The structure of GPCRs including GPR85 enables these receptors to extend across the cell membrane seven times which allows them to transmit signals from extracellular space into the cell.

Biological function summary

GPR85 plays a role in modulating neuronal signal transduction. It is part of the family of GPCRs that connects external signal molecules to internal cellular responses. Though GPR85 does not form multi-protein complexes often it influences neuronal functions and developmental processes. Its signaling can affect neurotransmitter release impacting brain function and neural connectivity.

Pathways

Researchers place GPR85 in pathways related to neurodevelopment and synaptic transmission. GPR85 involves itself in the GPCR signaling pathway and neuroactive ligand-receptor interaction path. It relates to proteins like GPR84 and other GPCRs sharing signaling mechanisms that influence brain physiology. GPR85 can carry out vital functions that connect extracellular signals with intracellular activities important for neuronal health.

Associated diseases and disorders

Scientists associate GPR85 with schizophrenia and cognitive disorders. Alterations in GPR85 expression or function may contribute to these conditions potentially disrupting normal neural signaling and connectivity. GPR85 might interact with proteins such as GPR88 which are also involved in cognitive functions suggesting a complex network of GPCRs in maintaining proper mental health. Understanding these interactions helps in developing therapeutic approaches for brain-related disorders.