AB188901

Anti-GPCR GPR87 antibody - C-terminal

Name: Anti-GPCR GPR87 antibody - C-terminal (ab188901) | Abcam
Brand: Abcam Limited
SKU: AB188901

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(2 Publications)

Rabbit Polyclonal GPCR GPR87 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GPR87.

View Alternative Names

GPR95, FKSG78, GPR87, G-protein coupled receptor 87, G-protein coupled receptor 95

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR87 antibody - C-terminal (AB188901)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR87 antibody - C-terminal (AB188901)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate epithelium labeling GPCR GPR87 with ab188901 at 14 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPR87. The exact immunogen used to generate this antibody is proprietary information.

Q9BY21

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except YSK4 (63%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6-14 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPCR GPR87 also known as G protein-coupled receptor 87 is a transmembrane receptor involved in various signaling processes. It has a molecular weight of approximately 42 kDa. GPR87 is expressed in various tissues with higher levels in certain cancers such as lung and bladder cancers. This receptor belongs to the large GPCR family which functions in transmitting signals from outside the cell to the inside leading to various cellular responses.

Biological function summary

In mediating cellular communication GPR87 plays a role in autocrine signaling mechanisms. It is not typically part of a larger complex but works closely with ligands and other signaling molecules to exert its effects. Studies indicate that GPR87 activation could promote cell proliferation and survival particularly in cancerous tissues suggesting a role in oncogenic pathways and cellular homeostasis.

Pathways

Multiple studies indicate that GPR87 participates in the p53 and Wnt signaling pathways. It might modulate the expression of target proteins such as p53 which is an important player in cell cycle regulation and apoptosis. GPR87 interacts with other proteins within these pathways potentially contributing to the regulatory loops that control cell fate and proliferation.

Researchers link GPR87 with lung and bladder cancer due to its overexpression in these tissues. It correlates with tumor aggression and poor prognosis indicating its role in cancer progression. The p53 protein a well-known tumor suppressor interacts with GPR87 adding complexity to the regulatory networks involved in these cancers. Understanding GPR87's contributions to these diseases may offer insights for developing targeted therapies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

See full target information GPR87

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 12:711145 PubMed34659201

2021

Development and Validation of a Combined Glycolysis and Immune Prognostic Model for Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Yaling Li,Ruiqun Qi,Lan Zhang

The Journal of physiology 595:6623-6634 PubMed28877347

2017

Sex differences in the role of phospholipase A -dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Abdulla A Ahmad,Michael D Randall,Richard E Roberts

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GPCR GPR87 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR87 antibody - C-terminal (AB188901)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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