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Rabbit Polyclonal GPCR GPR87 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR87.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human GPR87. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BY21
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted
Cow
Predicted
Dog
Predicted
Gorilla
Predicted
Hamster
Predicted
Horse
Predicted
Monkey
Predicted
Pig
Predicted
Rabbit
Predicted

Tested
Tested

Species

Human

Dilution info

6.00000-14.00000 µg/mL

Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Rat, Rabbit, Horse, Hamster, Cow, Dog, Pig, Gorilla, Monkey

Dilution info

-

Notes

-

Target data

Function

Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

Alternative names

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Rabbit Polyclonal GPCR GPR87 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR87.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Synthetic Peptide within Human GPR87. The exact immunogen used to generate this antibody is proprietary information.Database link Q9BY21

Purification technique

Affinity purification Immunogen

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except YSK4 (63%).

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological summary

In mediating cellular communication GPR87 plays a role in autocrine signaling mechanisms. It is not typically part of a larger complex but works closely with ligands and other signaling molecules to exert its effects. Studies indicate that GPR87 activation could promote cell proliferation and survival particularly in cancerous tissues suggesting a role in oncogenic pathways and cellular homeostasis.

Mechanical summary

GPCR GPR87 also known as G protein-coupled receptor 87 is a transmembrane receptor involved in various signaling processes. It has a molecular weight of approximately 42 kDa. GPR87 is expressed in various tissues with higher levels in certain cancers such as lung and bladder cancers. This receptor belongs to the large GPCR family which functions in transmitting signals from outside the cell to the inside leading to various cellular responses.

Pathway

Multiple studies indicate that GPR87 participates in the p53 and Wnt signaling pathways. It might modulate the expression of target proteins such as p53 which is an important player in cell cycle regulation and apoptosis. GPR87 interacts with other proteins within these pathways potentially contributing to the regulatory loops that control cell fate and proliferation.

Disease

Researchers link GPR87 with lung and bladder cancer due to its overexpression in these tissues. It correlates with tumor aggression and poor prognosis indicating its role in cancer progression. The p53 protein a well-known tumor suppressor interacts with GPR87 adding complexity to the regulatory networks involved in these cancers. Understanding GPR87's contributions to these diseases may offer insights for developing targeted therapies.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR87 antibody - C-terminal (ab188901), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR87 antibody - C-terminal (ab188901)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate epithelium labeling GPCR GPR87 with ab188901 at 14 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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