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AB188745

Anti-GPCR GPRC5D antibody - Cytoplasmic domain

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(1 Publication)

Rabbit Polyclonal GPCR GPRC5D antibody. Cytoplasmic domain. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPRC5D.

View Alternative Names

G-protein coupled receptor family C group 5 member D, GPRC5D

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPRC5D antibody - Cytoplasmic domain (AB188745)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPRC5D antibody - Cytoplasmic domain (AB188745)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human tonsil tissue labeling GPCR GPRC5D with ab188745 at 20 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPRC5D. The exact immunogen used to generate this antibody is proprietary information.

Q9NZD1

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR GPRC5D also known as the GPRC5D protein or by the code 6D9 in certain research contexts is a member of the G-protein-coupled receptors (GPCRs) superfamily. This family acts as a significant mediator of cellular responses to external signals. The GPRC5D has a mass of approximately 56 kDa. It is mainly expressed in the human bone marrow and the keratinocytes of the skin with notable absence in other tissues. It also appears in certain immune cells indicating its potential involvement in immune system responses.
Biological function summary

The role of GPCR GPRC5D centers on cell signaling mechanisms within the immune system. GPCR GPRC5D engages in intracellular signaling cascades that modulate immune functions although it is not known to be part of a larger receptor complex. Its function may involve interactions with molecules that transmit environmental signals into cellular responses enhancing its importance in immune regulation and possibly other cellular functions.

Pathways

GPCR GPRC5D participates in signaling pathways like the immune regulation pathway and the skin development pathway. It relates to proteins such as arrestins which link GPCRs to downstream signaling pathways. This connection hints at a regulatory role in cellular response where GPCR GPRC5D acts as a conduit for signal transduction balancing cellular responses to external stimuli and maintaining cellular homeostasis.

GPCR GPRC5D has associations with multiple myeloma and psoriasis. Its expression in bone marrow links it to multiple myeloma where its level might impact cancer progression. Proteins such as interleukin-17 and others relevant to psoriasis are connected to GPCR GPRC5D through skin-related pathways suggesting its role in inflammatory responses and potential as a therapeutic target for skin disorders. This illustrates GPRC5D's relevance in specific pathological conditions offering avenues for research into targeted treatments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

G-protein coupled receptor involved in hard keratin expression and likely plays a role in the development of hair and nails.
See full target information GPRC5D
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 6:35205 PubMed27748416

2016

MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection.

Applications

Unspecified application

Species

Unspecified reactive species

Qin-Qin He,Liu-Lin Xiong,Fei Liu,Xiang He,Guo-Ying Feng,Fei-Fei Shang,Qing-Jie Xia,You-Cui Wang,De-Lu Qiu,Chao-Zhi Luo,Jia Liu,Ting-Hua Wang
View all publications
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Product promise

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