Goat Polyclonal GPCR TAS1R2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Taste receptor type 1 member 2 aa 450-550.
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Primates | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1.00000-3.00000 µg/mL | Notes 1 hour primary incubation is recommended for this product. |
Species | Dilution info | Notes |
---|---|---|
Species Primates | Dilution info - | Notes - |
Select an associated product type
Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
GPR71, T1R2, TR2, TR2, T1R2, GPR71, TAS1R2, Taste receptor type 1 member 2, G-protein coupled receptor 71, Sweet taste receptor T1R2
Goat Polyclonal GPCR TAS1R2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Taste receptor type 1 member 2 aa 450-550.
IgG
Goat
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline
Liquid
Polyclonal
Affinity purification Immunogen
ab77346 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunising peptide.
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The GPCR TAS1R2 also known as Taste Receptor Type 1 Member 2 is part of the G protein-coupled receptor family. The molecular weight of TAS1R2 is around 90 kDa. This receptor is mainly expressed in taste buds on the tongue particularly in the taste receptor cells. TAS1R2 interacts mechanistically with other receptors by forming heterodimers particularly with TAS1R3. This interaction allows it to function effectively in sensing sweet substances.
The TAS1R2 receptor plays a significant role in taste perception by functioning as a part of the heterodimer with TAS1R3. This dimer predominantly detects sweet-tasting compounds and some amino acids. As such TAS1R2 contributes to dietary choices and calorie intake regulation. Additionally researchers have identified its presence in other tissues like the pancreas suggesting it may have roles outside taste perception.
TAS1R2 integrates into signaling pathways that mediate taste transduction. It notably participates in the sweet taste transduction pathway which affects the release of neurotransmitters triggered by sweet molecules. Additionally TAS1R2 is involved in the insulin secretion pathway via its action in pancreatic cells where it interacts with proteins involved in metabolic regulation.
TAS1R2 has associations with conditions such as obesity and type 2 diabetes. Variations in the TAS1R2 gene may influence individual taste preferences and energy balance potentially leading to an increased risk of obesity. Furthermore in type 2 diabetes alterations in sweet taste receptor function can affect insulin release and glucose homeostasis. In this context TAS1R2's interaction with TAS1R3 and other metabolic proteins highlights its importance in maintaining normal metabolic functions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Primary incubation was 1 hour. Detected by chemiluminescence.
All lanes: Western blot - Anti-GPCR TAS1R2 antibody (ab77346) at 0.3 µg/mL
All lanes: Human pancreas lysate in RIPA buffer at 35 µg
Predicted band size: 95 kDa
Observed band size: 100 kDa
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