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Goat Polyclonal GPCR TAS1R2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Taste receptor type 1 member 2 aa 450-550.


Images

Western blot - Anti-GPCR TAS1R2 antibody (AB77346), expandable thumbnail

Publications

Key facts

Isotype

IgG

Host species

Goat

Storage buffer

pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human Taste receptor type 1 member 2 aa 450-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TE23

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Primates
Predicted

Tested
Tested

Species

Human

Dilution info

1.00000-3.00000 µg/mL

Notes

1 hour primary incubation is recommended for this product.

Predicted
Predicted

Species

Primates

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.

Alternative names

Recommended products

Goat Polyclonal GPCR TAS1R2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Taste receptor type 1 member 2 aa 450-550.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human Taste receptor type 1 member 2 aa 450-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TE23
Purification technique

Affinity purification Immunogen

Concentration
Loading...
Purification notes

ab77346 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunising peptide.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The GPCR TAS1R2 also known as Taste Receptor Type 1 Member 2 is part of the G protein-coupled receptor family. The molecular weight of TAS1R2 is around 90 kDa. This receptor is mainly expressed in taste buds on the tongue particularly in the taste receptor cells. TAS1R2 interacts mechanistically with other receptors by forming heterodimers particularly with TAS1R3. This interaction allows it to function effectively in sensing sweet substances.

Biological function summary

The TAS1R2 receptor plays a significant role in taste perception by functioning as a part of the heterodimer with TAS1R3. This dimer predominantly detects sweet-tasting compounds and some amino acids. As such TAS1R2 contributes to dietary choices and calorie intake regulation. Additionally researchers have identified its presence in other tissues like the pancreas suggesting it may have roles outside taste perception.

Pathways

TAS1R2 integrates into signaling pathways that mediate taste transduction. It notably participates in the sweet taste transduction pathway which affects the release of neurotransmitters triggered by sweet molecules. Additionally TAS1R2 is involved in the insulin secretion pathway via its action in pancreatic cells where it interacts with proteins involved in metabolic regulation.

Associated diseases and disorders

TAS1R2 has associations with conditions such as obesity and type 2 diabetes. Variations in the TAS1R2 gene may influence individual taste preferences and energy balance potentially leading to an increased risk of obesity. Furthermore in type 2 diabetes alterations in sweet taste receptor function can affect insulin release and glucose homeostasis. In this context TAS1R2's interaction with TAS1R3 and other metabolic proteins highlights its importance in maintaining normal metabolic functions.

Product promise

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1 product image

  • Western blot - Anti-GPCR TAS1R2 antibody (ab77346), expandable thumbnail

    Western blot - Anti-GPCR TAS1R2 antibody (ab77346)

    Primary incubation was 1 hour. Detected by chemiluminescence.

    All lanes: Western blot - Anti-GPCR TAS1R2 antibody (ab77346) at 0.3 µg/mL

    All lanes: Human pancreas lysate in RIPA buffer at 35 µg

    Predicted band size: 95 kDa

    Observed band size: 100 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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