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AB77346

Anti-GPCR TAS1R2 antibody

1

(1 Review)

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(1 Publication)

Goat Polyclonal GPCR TAS1R2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAS1R2 aa 450-550.

View Alternative Names

GPR71, T1R2, TR2, TAS1R2, Taste receptor type 1 member 2, G-protein coupled receptor 71, Sweet taste receptor T1R2

1 Images
Western blot - Anti-GPCR TAS1R2 antibody (AB77346)
  • WB

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Western blot - Anti-GPCR TAS1R2 antibody (AB77346)

Primary incubation was 1 hour. Detected by chemiluminescence.

All lanes:

Western blot - Anti-GPCR TAS1R2 antibody (ab77346) at 0.3 µg/mL

All lanes:

Human pancreas lysate in RIPA buffer at 35 µg

Predicted band size: 95 kDa

Observed band size: 100 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TAS1R2 aa 450-550. The exact immunogen used to generate this antibody is proprietary information.

Q8TE23

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Alternative Products

Primary Antibodies

AB150495

Anti-GPCR TAS1R2 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR TAS1R2 antibody - N-terminal (AB150495)

  • 0
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Complementary Products

Primary Antibodies

AB150525

Anti-T1R3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T1R3 antibody (AB150525)

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Primary Antibodies

AB222859

Anti-TAS2R38 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAS2R38 antibody (AB222859)

  • 0
  • 0
Primary Antibodies

AB138271

Anti-TAS2R14 antibody

Western blot - Anti-TAS2R14 antibody (AB138271)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Primates": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab77346 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunising peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.5% Tris buffered saline
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GPCR TAS1R2 also known as Taste Receptor Type 1 Member 2 is part of the G protein-coupled receptor family. The molecular weight of TAS1R2 is around 90 kDa. This receptor is mainly expressed in taste buds on the tongue particularly in the taste receptor cells. TAS1R2 interacts mechanistically with other receptors by forming heterodimers particularly with TAS1R3. This interaction allows it to function effectively in sensing sweet substances.
Biological function summary

The TAS1R2 receptor plays a significant role in taste perception by functioning as a part of the heterodimer with TAS1R3. This dimer predominantly detects sweet-tasting compounds and some amino acids. As such TAS1R2 contributes to dietary choices and calorie intake regulation. Additionally researchers have identified its presence in other tissues like the pancreas suggesting it may have roles outside taste perception.

Pathways

TAS1R2 integrates into signaling pathways that mediate taste transduction. It notably participates in the sweet taste transduction pathway which affects the release of neurotransmitters triggered by sweet molecules. Additionally TAS1R2 is involved in the insulin secretion pathway via its action in pancreatic cells where it interacts with proteins involved in metabolic regulation.

TAS1R2 has associations with conditions such as obesity and type 2 diabetes. Variations in the TAS1R2 gene may influence individual taste preferences and energy balance potentially leading to an increased risk of obesity. Furthermore in type 2 diabetes alterations in sweet taste receptor function can affect insulin release and glucose homeostasis. In this context TAS1R2's interaction with TAS1R3 and other metabolic proteins highlights its importance in maintaining normal metabolic functions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
See full target information TAS1R2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 124:1393-405 PubMed24531552

2014

Bitter and sweet taste receptors regulate human upper respiratory innate immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Robert J Lee,Jennifer M Kofonow,Philip L Rosen,Adam P Siebert,Bei Chen,Laurel Doghramji,Guoxiang Xiong,Nithin D Adappa,James N Palmer,David W Kennedy,James L Kreindler,Robert F Margolskee,Noam A Cohen
View all publications
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Product promise

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