Rabbit Polyclonal GPCR TM7SF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR137B aa 300 to C-terminus.
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Publications
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- Molecular medicine reports 16:6122-61272017Downregulation of TM7SF4 inhibits cell proliferation and metastasis of A549 cells through regulating the PI3K/AKT/mTOR signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXudong Yang et. al.PubMed 28849122
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GPR137B aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O60478
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 | Notes - |
Target data
Function
Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Alternative names
TM7SF1, GPR137B, Integral membrane protein GPR137B, Transmembrane 7 superfamily member 1 protein
Recommended products
Rabbit Polyclonal GPCR TM7SF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR137B aa 300 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GPR137B aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O60478
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein GPCR TM7SF1 also known as GPR103 is a member of the G protein-coupled receptor family. It consists of seven transmembrane domains and has a molecular mass of approximately 46 kDa. Researchers have found that GPCR TM7SF1 is expressed in various tissues including the brain heart and peripheral blood leukocytes. This expression pattern suggests its involvement in multiple physiological processes. GPCR TM7SF1 interacts with specific ligands triggering intracellular signaling cascades that modulate cellular responses.
- Biological function summary
GPCR TM7SF1 plays a significant role in neuropeptide signaling pathways. It is not a standalone entity; it generally interacts with other receptors and proteins to form functional complexes. It facilitates neurotransmitter release and modulates synaptic plasticity which are important for brain communication and adaptation. This receptor contributes to the regulation of physiological responses such as appetite stress and energy balance indicating its importance in maintaining homeostasis.
- Pathways
GPCR TM7SF1 is importantly involved in the neuropeptide Y receptor pathways and the hypothalamic-pituitary-adrenal axis. These pathways are important for controlling appetite and stress responses. GPCR TM7SF1 interacts with other proteins including neuropeptide Y receptors and corticotropin-releasing hormone receptors. These interactions provide diverse signaling outputs synchronizing various metabolic and stress-related processes within the organism.
- Associated diseases and disorders
GPCR TM7SF1 has been linked to obesity and anxiety disorders. Abnormal activation or expression of this receptor can contribute to dysregulation in appetite control predisposing individuals to obesity. Additionally its involvement in stress response pathways connects it to anxiety disorders where an imbalance in stress hormone signaling may occur. The receptor's interaction with neuropeptide Y and corticotropin-releasing hormone receptors further highlights its influence in these conditions offering potential targets for therapeutic interventions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-GPCR TM7SF1 antibody (ab96809)
10% SDS PAGE
All lanes: Western blot - Anti-GPCR TM7SF1 antibody (ab96809) at 1/1000 dilution
All lanes: HepG2 cell lysate at 30 µg
Predicted band size: 46 kDa
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