Anti-GPM6B antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The glycoprotein M6B commonly known as GPM6B is a membrane glycoprotein that belongs to the proteolipid protein family. This protein has a molecular mass of approximately 33 kilodaltons. GPM6B is expressed in various tissues with a strong presence in the brain particularly in neurons and glial cells. It is also found in bone and platelets indicating its diverse roles in different physiological contexts.

Biological function summary

The glycoprotein M6B contributes to several cellular processes such as neurite outgrowth and synapse assembly. It is known to participate in myelination and cell adhesion activities. Researchers have identified GPM6B to be part of a membrane microdomain where it may work with other proteins to mediate these cellular interactions. Its role in bone homeostasis further highlights its biological significance across distinct cellular environments.

Pathways

Glycoprotein M6B is significantly involved in the calcium signaling pathway and the integrin signaling pathway. Within these pathways GPM6B works in conjunction with integrins and calcium channels influencing cellular responses to mechanical stimuli and cell-extracellular matrix adhesion. These pathways highlight GPM6B's role in maintaining cellular structure and signaling transduction as they contribute to broader cellular functionalities.

Associated diseases and disorders

Abnormal expression or mutations of glycoprotein M6B have been linked to neurological disorders like autism spectrum disorder and the bone disease osteoporosis. The involvement of GPM6B in these conditions may also relate to its interaction with proteins such as integrins. These interactions can affect cellular procedures critically important for maintaining neural network connectivity and bone density revealing therapeutic research potential.