JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB129879

Anti-GPR 139 antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal GPR 139 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR139.

View Alternative Names

GPRG1, PGR3, GPR139, Probable G-protein coupled receptor 139, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-GPR 139 antibody (AB129879)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPR 139 antibody (AB129879)

ab129879 at 1/100 dilution staining GPR 139 in LOVO cells by Immunofluroescence. The image on the right is treated with the synthesised peptide

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human GPR139. The exact immunogen used to generate this antibody is proprietary information.

Q6DWJ6

style
left-column

Alternative Products

Primary Antibodies

AB155983

Anti-GPR 139 antibody [EPR10766]

RabMAb|Recombinant

Western blot - Anti-GPR 139 antibody [EPR10766] (AB155983)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB75973

Anti-Ferritin heavy chain antibody [EPR3004Y]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Ferritin heavy chain antibody [EPR3004Y] (AB75973)

  • 4
  • 7
Primary Antibodies

AB260033

Anti-G-protein coupled receptor 30 antibody [EPR23701-79]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-G-protein coupled receptor 30 antibody [EPR23701-79] (AB260033)

  • 5
  • 1
Primary Antibodies

AB245116

Anti-Flt3 / CD135 antibody [EPR22232-318]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-Flt3 / CD135 antibody [EPR22232-318] (AB245116)

  • 0
  • 0
Primary Antibodies

AB267351

Anti-TFEB antibody [EPR22941-6]

BOND RX™ Validated|Advanced Validation|RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-TFEB antibody [EPR22941-6] (AB267351)

  • 5
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab129879 is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR139 known also as G protein-coupled receptor 139 is a member of the rhodopsin family of G protein-coupled receptors (GPCRs). It has an approximate mass of 37 kDa. This receptor mainly expresses in the central nervous system specifically in the thalamus habenula and hypothalamus. It is part of the larger group of products encoded by GPCR genes which play significant roles in signal transduction across cell membranes.
Biological function summary

GPR139 acts as a modulator within the brain's neurochemical network. Although not part of a larger complex it influences neurotransmitter systems by transducing extracellular signals through intramembrane effects affecting physiological processes like mood circadian rhythms and pain perception. Researchers continue to explore its ligands such as L-tryptophan and L-phenylalanine which may provide further insight into its specific regulatory roles.

Pathways

The functionality of GPR139 intersects with neuronal signaling pathways like the cAMP signaling pathway. This pathway impacts cellular processes by modulating enzymes and transcription factors relevant to intracellular signaling. GPR139's activity also relates to that of other GPCRs such as GPR88 which influences similar neurological functions and developmental pathways in neurons.

GPR139 is mainly associated with neurological disorders and mental health conditions. Some studies link it to addiction and schizophrenia as it interacts with systems that regulate mood and reward. Through its association with dopamine D2 receptors GPR139 might influence disorders related to dopaminergic function offering a potential target for therapeutic interventions in these areas.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
See full target information GPR139
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecules (Basel, Switzerland) 25: PubMed33081083

2020

A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Romain Duroux,Anne Mandeau,Gaelle Guiraudie-Capraz,Yannick Quesnel,Estelle Loing
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com