AB155983

Anti-GPR 139 antibody [EPR10766]

RabMAb
Recombinant
What is this?

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(1 Publication)

Rabbit Recombinant Monoclonal GPR 139 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

GPRG1, PGR3, GPR139, Probable G-protein coupled receptor 139, G(q)-coupled orphan receptor GPRg1, G-protein-coupled receptor PGR3

1 Images

Unknown

Western blot - Anti-GPR 139 antibody [EPR10766] (AB155983)

All lanes:

Western blot - Anti-GPR 139 antibody [EPR10766] (ab155983) at 1/1000 dilution

Lane 1:

U-87 MG cell lysate at 10 µg

Lane 2:

SH SY5Y cell lysate at 10 µg

Lane 3:

HeLa cell lysate at 10 µg

Predicted band size: 41 kDa

false

Carrier free

Anti-GPR 139 antibody [EPR10766] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10766

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR139 known also as G protein-coupled receptor 139 is a member of the rhodopsin family of G protein-coupled receptors (GPCRs). It has an approximate mass of 37 kDa. This receptor mainly expresses in the central nervous system specifically in the thalamus habenula and hypothalamus. It is part of the larger group of products encoded by GPCR genes which play significant roles in signal transduction across cell membranes.

Biological function summary

GPR139 acts as a modulator within the brain's neurochemical network. Although not part of a larger complex it influences neurotransmitter systems by transducing extracellular signals through intramembrane effects affecting physiological processes like mood circadian rhythms and pain perception. Researchers continue to explore its ligands such as L-tryptophan and L-phenylalanine which may provide further insight into its specific regulatory roles.

Pathways

The functionality of GPR139 intersects with neuronal signaling pathways like the cAMP signaling pathway. This pathway impacts cellular processes by modulating enzymes and transcription factors relevant to intracellular signaling. GPR139's activity also relates to that of other GPCRs such as GPR88 which influences similar neurological functions and developmental pathways in neurons.

GPR139 is mainly associated with neurological disorders and mental health conditions. Some studies link it to addiction and schizophrenia as it interacts with systems that regulate mood and reward. Through its association with dopamine D2 receptors GPR139 might influence disorders related to dopaminergic function offering a potential target for therapeutic interventions in these areas.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

See full target information GPR139

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Methods in molecular biology (Clifton, N.J.) 2557:453-493 PubMed36512231

2022

Common Markers and Small Molecule Inhibitors in Golgi Studies.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Bui,Drew Stark,Jie Li,Jianchao Zhang,Yanzhuang Wang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GPR 139 antibody [EPR10766]

Western blot - Anti-GPR 139 antibody [EPR10766] (AB155983)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise