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AB122267

Anti-GPR112 antibody

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(1 Publication)

Rabbit Polyclonal GPR112 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADGRG4 aa 2400-2550.

View Alternative Names

GPR112, ADGRG4, Adhesion G-protein coupled receptor G4, G-protein coupled receptor 112

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR112 antibody (AB122267)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR112 antibody (AB122267)

ab122267, at a 1/50 dilution, staining GPR112 in paraffin embedded Human colon tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ADGRG4 aa 2400-2550. The exact immunogen used to generate this antibody is proprietary information.

Q8IZF6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR112 also known as ADGRG5 is a G protein-coupled receptor (GPCR) that is involved in various cellular signaling processes. The molecular mass of GPR112 is approximately 164 kDa. It is predominantly expressed in the brain tissues particularly in regions like the cerebellum. This receptor is part of the adhesion GPCR family which is characterized by its long N-terminal tail that is essential for its signaling activity and interaction with other proteins.
Biological function summary

GPR112 plays roles in cellular communication and development. It is not part of a simple receptor-ligand interaction but is instead involved in complex signaling networks that regulate neural functions. Studies have indicated its involvement in the modulation of neurotransmission and potentially influencing the formation of synaptic structures. Its expression in the brain suggests its importance in cognitive functions and neural maintenance.

Pathways

GPR112 engages in signaling cascades related to neuronal development and neuroplasticity. It notably participates in the Wnt signaling pathway which is important for cell proliferation and differentiation. Through this pathway GPR112 interacts with other proteins like Dishevelled an important player in transmitting Wnt signals to the cellular nucleus. Such interactions suggest its role in regulating embryonic development and adult brain function.

GPR112 has been implicated in neurological conditions such as autism spectrum disorders and schizophrenia. Its aberrant expression or mutation may lead to synaptic deficits or dysfunctional communication between neurons. The protein's involvement with other GPCRs like GPR56 highlights its potential contributions to the pathophysiology of these neurodevelopmental conditions making it a point of interest for therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Orphan receptor.
See full target information ADGRG4
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Renal physiology 317:F1593-F1604 PubMed31566424

2019

Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion.

Applications

Unspecified application

Species

Unspecified reactive species

Davide P Cinà,Troy Ketela,Kevin R Brown,Megha Chandrashekhar,Patricia Mero,Chengjin Li,Tuncer Onay,Yulong Fu,Zhe Han,Moin Saleem,Jason Moffat,Susan E Quaggin
View all publications
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Product promise

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