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AB122814

Anti-GPR123 antibody

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(1 Publication)

Rabbit Polyclonal GPR123 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADGRA1 aa 350-500.
2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR123 antibody (AB122814)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR123 antibody (AB122814)

ab122814, at 1/50 dilution, staining GPR123 in formalin-fixed, paraffin-embedded Human testis tissue by immunohistohemistry.

Immunocytochemistry/ Immunofluorescence - Anti-GPR123 antibody (AB122814)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPR123 antibody (AB122814)

ab122814, at 4μg/ml, staining GPR123 in U-2 OS cells by immunofluorescence.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ADGRA1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.

Q86SQ6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR123 also known as Probable G-protein coupled receptor 123 is a member of the adhesion GPCR family. This receptor has a molecular mass of approximately 85 kDa. GPR123 primarily expresses in the central nervous system including regions like the brain and spinal cord. Researchers have identified GPR123's structure as containing several conserved domains common to the GPCR superfamily which play an important role in signal transduction across cell membranes.
Biological function summary

Adhesion GPCRs like GPR123 participate in various cellular processes often interacting with extracellular matrix components. GPR123 does not act in isolation but forms part of larger protein complexes essential for cell signaling. In neural tissues GPR123 is involved in processes related to cell adhesion migration and possibly axon guidance. Understanding its interactions can help illuminate its contribution to neural development and function.

Pathways

GPR123 likely integrates into the Wnt and MAPK signaling pathways which are critical for numerous cellular functions including proliferation and differentiation. Within these pathways GPR123 might work in conjunction with proteins like beta-catenin and MAPK kinases to modulate downstream effects. These pathways are significant in neural tissues suggesting GPR123's role in neural activity and development.

The specific functions of GPR123 link to neurological conditions such as epilepsy and schizophrenia. Dysfunction in GPR123-mediated signaling might lead to aberrant neural development or activity contributing to these disorders. In the case of epilepsy proteins related to GPR123 in pathways like the Wnt cascade including APC and Axin might also interact during disease pathology. For schizophrenia disruptions in pathways where GPR123 intersects could influence gene regulation and synaptic plasticity connecting it to proteins involved in neurotransmission.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Orphan receptor.
See full target information ADGRA1

Alternative Names

GPR123, KIAA1828, ADGRA1, Adhesion G protein-coupled receptor A1, G-protein coupled receptor 123
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Genes & genomics 43:1317-1325 PubMed33945147

2021

Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yaming Liu,Guodong Wang,Tongwei Cui,Lin Lv
View all publications
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Product promise

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