Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Rabbit Polyclonal GPR133 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ADGRD1.
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Common marmoset | Predicted |
Gorilla | Predicted |
Monkey | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 15.00000-30.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Gorilla, Common marmoset, Monkey | Dilution info - | Notes - |
Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701).
Adhesion G-protein coupled receptor D1, G-protein coupled receptor 133, G-protein coupled receptor PGR25, ADGRD1, GPR133, PGR25
Rabbit Polyclonal GPR133 antibody. N-terminal. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human ADGRD1.
Adhesion G-protein coupled receptor D1, G-protein coupled receptor 133, G-protein coupled receptor PGR25, ADGRD1, GPR133, PGR25
IgG
Rabbit
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Immunogen
BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except ENTPD4 (50%).
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Adhesion G protein-coupled receptor GPR133 has roles in cellular signaling and communication. It participates in the regulation of processes such as cell adhesion and migration. GPR133 does not act alone; it associates with other proteins to affect physiological functions though it is not strictly part of a larger protein complex. Its broad expression in several tissues indicates its functional versatility.
GPR133 also known as ADGRD1 is a member of the adhesion G protein-coupled receptor (GPCR) family. It possesses a large extracellular domain and a characteristic seven-transmembrane domain typical of GPCRs with a molecular mass approximately 100 kDa. GPR133 expresses broadly in the central nervous system and several peripheral tissues including the lung and heart. This pattern of expression suggests its involvement in various physiological functions.
Research links GPR133 to significant signaling pathways like the Wnt signaling pathway and the G-protein signaling pathway. It interacts with the proteins involved in these pathways to modulate their downstream effects impacting cellular processes such as proliferation and differentiation. Partner proteins such as heterotrimeric G proteins directly associate with GPR133 playing roles in the signal transduction processes initiated by this receptor.
GPR133 associates with conditions such as glioblastoma and asthma. It often operates alongside other proteins involved in these conditions such as EGFR in glioblastoma and the IL-4 receptor in asthma. Alterations in the expression or function of GPR133 may contribute to the pathogenesis of these diseases by affecting cell signaling pathways presenting it as a potential therapeutic target for intervention.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Immunohistochemical analysis of formalin/PFA fixed paraffin embedded Human ovary epithelium tissue sections labeling GPR133 using ab188637 at 30 μg/ml.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com