Anti-GPR133 antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPR133 also known as ADGRD1 is a member of the adhesion G protein-coupled receptor (GPCR) family. It possesses a large extracellular domain and a characteristic seven-transmembrane domain typical of GPCRs with a molecular mass approximately 100 kDa. GPR133 expresses broadly in the central nervous system and several peripheral tissues including the lung and heart. This pattern of expression suggests its involvement in various physiological functions.

Biological function summary

Adhesion G protein-coupled receptor GPR133 has roles in cellular signaling and communication. It participates in the regulation of processes such as cell adhesion and migration. GPR133 does not act alone; it associates with other proteins to affect physiological functions though it is not strictly part of a larger protein complex. Its broad expression in several tissues indicates its functional versatility.

Pathways

Research links GPR133 to significant signaling pathways like the Wnt signaling pathway and the G-protein signaling pathway. It interacts with the proteins involved in these pathways to modulate their downstream effects impacting cellular processes such as proliferation and differentiation. Partner proteins such as heterotrimeric G proteins directly associate with GPR133 playing roles in the signal transduction processes initiated by this receptor.

Associated diseases and disorders

GPR133 associates with conditions such as glioblastoma and asthma. It often operates alongside other proteins involved in these conditions such as EGFR in glioblastoma and the IL-4 receptor in asthma. Alterations in the expression or function of GPR133 may contribute to the pathogenesis of these diseases by affecting cell signaling pathways presenting it as a potential therapeutic target for intervention.