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Rabbit Recombinant Monoclonal GPR176 antibody. N-terminal. Suitable for WB and reacts with Human samples.

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Images

Western blot - Anti-GPR176 antibody [EPR13983] - N-terminal (AB184558), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Mouse
Predicted
Rat
Predicted

Tested
Tested

Species
Human
Dilution info
1/1000 - 1/2000
Notes

-

Predicted
Predicted

Species
Mouse, Rat
Dilution info
-
Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production.

Alternative names

G-protein coupled receptor 176, HB-954, GPR176

Recommended products

Rabbit Recombinant Monoclonal GPR176 antibody. N-terminal. Suitable for WB and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR13983
Purification technique
Affinity purification Protein A
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

GPR176 also known as G protein-coupled receptor 176 is a member of the G protein-coupled receptor family. The receptor has a molecular mass of around 47 kDa. Usually you find it expressed in various tissues including the brain and lymphoid organs. As a GPCR GPR176 may act through activating specific G proteins that transmit signals inside cells leading to various cellular responses.

Biological function summary

GPR176 shows roles in regulating circadian rhythms and immune system functions. It appears not to form a complex but influences biological processes through its signaling pathways. Evidence suggests that it modulates certain aspects of the immune response by impacting the behavior of immune cells.

Pathways

GPR176 participates in pathways connected to the regulation of circadian rhythms and immune system signaling. It interacts with pathways involving other GPCRs which are critical for maintaining physiological homeostasis. Proteins such as CLOCK and PER1 in the circadian rhythm pathway are related to the actions of GPR176 helping coordinate daily physiological cycles.

Associated diseases and disorders

Researchers link GPR176 to conditions like immune dysfunction and mood disorders. In particular dysregulation of circadian rhythms can have ties with mood disorders where GPR176 plays a role. The target also shows relevance to immune-related conditions interconnected with proteins like NF-kB which influence inflammation and immune responses.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Western blot - Anti-GPR176 antibody [EPR13983] - N-terminal (ab184558), expandable thumbnail

    Western blot - Anti-GPR176 antibody [EPR13983] - N-terminal (ab184558)

    All lanes: Western blot - Anti-GPR176 antibody [EPR13983] - N-terminal (ab184558) at 1/1000 dilution

    Lane 1: Human fetal brain tissue lysate at 20 µg

    Lane 2: BxPC3 cell line lysate at 20 µg

    Lane 3: MCF7 cell line lysate at 20 µg

    Lane 4: SH SY5Y cell line lysate at 20 µg

    Secondary

    All lanes: Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 57 kDa

    Observed band size: 51 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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