JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB169136

Anti-GPR61 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal GPR61 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GPR61.

View Alternative Names

BALGR, GPCR3, GPR61, G-protein coupled receptor 61, Biogenic amine receptor-like G-protein coupled receptor

2 Images
Western blot - Anti-GPR61 antibody (AB169136)
  • WB

Unknown

Western blot - Anti-GPR61 antibody (AB169136)

All lanes:

Western blot - Anti-GPR61 antibody (ab169136) at 1 µg/mL

Lane 1:

GPR61 transfected 293T cell lysate at 15 µL

Lane 2:

Non transfected 293T cell lysate at 15 µL

Predicted band size: 49 kDa

false

Western blot - Anti-GPR61 antibody (AB169136)
  • WB

Unknown

Western blot - Anti-GPR61 antibody (AB169136)

All lanes:

Western blot - Anti-GPR61 antibody (ab169136) at 1 µg/mL

All lanes:

A431 cell lysate at 50 µg

Predicted band size: 49 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GPR61.

Q9BZJ8

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR61 also known as G protein-coupled receptor 61 belongs to the family of GPCRs. It has a molecular weight of roughly 44 kDa. This receptor expresses mainly in the central nervous system with higher concentration in brain regions such as the thalamus and hypothalamus. Like other GPCRs it likely interacts with heterotrimeric G proteins to transmit extracellular signals into the cell although specific ligands for GPR61 remain unidentified.
Biological function summary

GPR61 plays a role in neuronal signaling and possibly in modulating mood and cognition. It does not form known multi-protein complexes. However it interacts within signaling networks that influence neural pathways. Researchers consider GPR61 important in understanding neurochemical pathways that influence physiological processes although the exact mechanisms remain to be clearly defined.

Pathways

GPR61 activity affects key signal transduction routes in the brain. It interacts with the cAMP signaling pathway which impacts neurotransmitter release and neuronal development. GPR61 relates closely to other GPCRs like GPR62 and GPR63 in their contribution to brain signaling networks. This receptor also potentially influences metabolic pathways by modulating adipogenesis through yet undetermined partners in the adipose tissue.

Alterations in GPR61 function associate with conditions such as schizophrenia and obesity. In schizophrenia its dysregulation may disrupt normal brain signaling processes interacting indirectly with dopamine receptors that compound disease symptoms. Regarding obesity GPR61 is linked to metabolic dysregulation possibly through its influence on energy balance and fat storage associated with adiponectin signaling. Understanding these interactions remains critical for potential therapeutic targeting in these disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed : 28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed : 28827538). May be involved in the regulation of food intake and body weight (By similarity).
See full target information GPR61
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 53: PubMed41002028

2025

RNF4 and USP7 coordinate spatial regulation of SLX4 stability within the PML nuclear bodies.

Applications

Unspecified application

Species

Unspecified reactive species

Eunyoung Jung,Myung-Jin Kim,Orlando D Schärer,Yonghwan Kim
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB19356

Anti-ZHX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZHX1 antibody (AB19356)

  • 0
  • 0
Primary Antibodies

AB176594

Anti-ZZEF1 antibody

Immunoprecipitation - Anti-ZZEF1 antibody (AB176594)

  • 0
  • 0
Primary Antibodies

AB273052

Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-ZWINT antibody [EPR23440-96] - BSA and Azide free (AB273052)

  • 0
  • 0
Primary Antibodies

AB169163

Anti-TDU antibody

Immunocytochemistry/ Immunofluorescence - Anti-TDU antibody (AB169163)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com