JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB140767

Anti-GPR83 antibody - Extracellular domain

0

(1 Review)

|

(1 Publication)

Rabbit Polyclonal GPR83 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPR83.

View Alternative Names

GPR72, JP05, KIAA1540, GPR83, G-protein coupled receptor 83, G-protein coupled receptor 72

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR83 antibody - Extracellular domain (AB140767)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR83 antibody - Extracellular domain (AB140767)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain cortex (neuron) tissue labelling GPCR GPR72 with ab140767 at 9 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPR83. The exact immunogen used to generate this antibody is proprietary information.

Q9NYM4

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "9-18 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Opossum": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: 99% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR83 also known as GIR or G-protein coupled receptor 83 is a member of the class A rhodopsin-like family of G-protein coupled receptors (GPCRs). This receptor has a mass of approximately 47 kDa. GPR83 is expressed in several tissues with significant expression in the brain particularly in the hypothalamus and to a lesser extent in the cortex and brainstem. It is also found in immune system tissues like the thymus and lymph nodes suggesting roles in both neurological and immune functions.
Biological function summary

GPR83 engages in the regulation of neuroendocrine signaling. There is evidence that it affects appetite control and energy homeostasis implying a role in metabolic processes. GPR83 does not function as part of a larger receptor complex but interacts with other GPCRs or intracellular proteins to transmit extracellular signals into cells. Its activity can modulate synaptic transmission and impact behaviors linked to feeding and stress response.

Pathways

Protein interactions involving GPR83 connect mainly to neuropeptide Y (NPY) signaling and the broader GPCR signaling pathways. The receptor modulates signaling by potentially influencing second messenger systems such as cAMP. Proteins related to these pathways include NPY a neuropeptide that affects energy balance and various G-protein subunits that mediate downstream effects following GPR83 activation.

Altered GPR83 expression or signaling links to obesity and certain psychiatric conditions including anxiety-related disorders. High GPR83 activity has associations with increased fat storage and body weight potentially by downregulating activity through pathways with proteins like NPY and agouti-related peptide (AgRP) which are involved in appetite control. Additionally imbalance in GPR83 signaling might influence mood disorders linked to dysregulation of neural circuits involved in stress and emotion.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed : 27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity).
See full target information GPR83
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 22: PubMed34884737

2021

Gastrointestinal Dopamine in Inflammatory Bowel Diseases: A Systematic Review.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena Kurnik-Łucka,Paweł Pasieka,Patrycja Łączak,Marcin Wojnarski,Michał Jurczyk,Krzysztof Gil
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB237610

Anti-GPR83 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GPR83 antibody (AB237610)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB213149

Anti-HNF-1B antibody [EPR18644-13]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HNF-1B antibody [EPR18644-13] (AB213149)

  • 5
  • 1
Primary Antibodies

AB237811

Anti-ZNF695 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF695 antibody (AB237811)

  • 0
  • 0
Primary Antibodies

AB236887

Anti-TPPP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPPP2 antibody (AB236887)

  • 0
  • 0
Primary Antibodies

AB249120

Anti-S31 antibody [EPR10789(B)] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-S31 antibody [EPR10789(B)] - BSA and Azide free (AB249120)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com