Anti-GPR88 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPR88 also known as Striatum-Expressed Orphan G-Protein-Coupled Receptor is a receptor protein weighing approximately 41 kDa. It is encoded by the GPR88 gene and is part of the G-protein-coupled receptor (GPCR) family. This receptor is mostly found in the striatum an important brain region involved in motor control and cognitive functions. GPR88 influences intracellular processes by interacting with cells' G proteins activating signaling pathways inside the cell.

Biological function summary

GPR88 plays a role in regulating neurotransmitter activity in the brain. It is not known to be part of any larger complex but affects various neurotransmitter systems including dopamine and gamma-aminobutyric acid (GABA) which are critical for maintaining balance in neuronal signaling. By doing so GPR88 helps modulate mood movement and reward pathways contributing to behavior regulation.

Pathways

GPR88 has involvement in dopaminergic and glutamatergic signaling pathways. It interacts with proteins linked to these pathways such as dopamine receptors D1R and D2R. Through these pathways GPR88 influences synaptic plasticity and neuron excitability. Therefore its function ties into key neurobiological systems that affect overall brain activity and function.

Associated diseases and disorders

Research suggests a connection between GPR88 dysfunction and neuropsychiatric conditions such as schizophrenia and bipolar disorder. Aberrant signaling through pathways where GPR88 participates can affect dopamine levels which are often disrupted in these conditions. Moreover its interaction with other proteins such as D1R involves the pathophysiology of these disorders. Understanding GPR88's role further could lead to new therapeutic strategies for handling these complex diseases.