Anti-GPRC5A antibody - Extracellular domain

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GPRC5A also known as retinoic acid-induced gene 3 (RAIG3) is a protein that functions in the cellular environment as a G protein-coupled receptor (GPCR). This protein has a distinct mass of about 40 kDa. Scientists find GPRC5A expressed predominantly in epithelial tissues including the lung and pancreas. The expression level indicates its possible functional relevance in these regions.

Biological function summary

GPRC5A participates in the modulation of cell proliferation and differentiation. This receptor can interact with external retinoic acid stimuli and it appears to play a role in maintaining epithelial tissue homeostasis. Although not established as part of a larger protein complex GPRC5A's involvement in cellular growth processes suggests interactions with other signaling molecules within the cellular matrix.

Pathways

GPRC5A plays a role in the retinoic acid signaling pathway which influences gene expression related to cell growth and differentiation. Additionally the receptor is linked to the JAK/STAT pathway an important player in controlling gene regulation involved in proliferation and immune responses. In these pathways it can relate to proteins such as RAR which binds retinoic acid and STAT3 a transcription factor important in gene expression regulation.

Associated diseases and disorders

Alterations in GPRC5A expression can associate with different types of cancer particularly in the lungs. Studies suggest decreased GPRC5A levels might promote tumorigenesis through unregulated cell proliferation. In addition pancreatic cancer research shows a possible link between GPRC5A and aberrant cell signaling involving proteins like KRAS a well-known oncogene. Understanding these connections helps in considering GPRC5A as a potential therapeutic target for these malignancies.