JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB75499

Anti-GPRC5C antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal GPRC5C antibody. Suitable for WB and reacts with African green monkey, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GPRC5C.

View Alternative Names

RAIG3, PSEC0087, GPRC5C, G-protein coupled receptor family C group 5 member C, Retinoic acid-induced gene 3 protein, RAIG-3

1 Images
Western blot - Anti-GPRC5C antibody (AB75499)
  • WB

Unknown

Western blot - Anti-GPRC5C antibody (AB75499)

All lanes:

Western blot - Anti-GPRC5C antibody (ab75499) at 1/500 dilution

Lane 1:

RAW264.7 cell extract at 30 µg

Lane 2:

Cos-7 cell extract at 30 µg

Lane 3:

RAW264.7 cell extract at 30 µg with immunising peptide

Predicted band size: 48 kDa

Observed band size: 100 kDa,48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, African green monkey

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GPRC5C. The exact immunogen used to generate this antibody is proprietary information.

Q9NQ84

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "African green monkey": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPRC5C also known as G protein-coupled receptor family C group 5 member C acts as a cell surface receptor involved in various signaling processes. Weighing approximately 42 kilodaltons (kDa) this receptor is expressed in several human tissues including the lung kidney and liver. GPRC5C belongs to the group of G protein-coupled receptors which are important for mediating the effects of diverse extracellular signals into cellular responses.
Biological function summary

The function of GPRC5C involves interaction with G proteins to transmit signals within cells. The receptor does not operate in isolation but may form part of larger signaling complexes. Through its signaling activities GPRC5C can influence cellular processes such as growth and differentiation. Its expression pattern suggests roles in both normal physiological processes and in responses to environmental changes.

Pathways

Proteins like GPRC5C participate in important processes like cell survival and proliferation. It intersects the MAPK (mitogen-activated protein kinase) pathway an important signaling cascade for cellular growth responses. In this pathway GPRC5C can interact with proteins such as ERK (extracellular signal-regulated kinase) and other G proteins to modulate cell signaling dynamics affecting how cells respond to external stimuli.

Alterations in GPRC5C expression or function link to cancer and inflammatory diseases. Aberrant signaling through GPRC5C can contribute to uncontrolled cell growth characteristic in certain cancers with proteins like ERK playing complementary roles in these processes. Additionally improper GPRC5C activity may influence inflammatory pathways associating it with conditions where immune responses become dysregulated. Understanding GPRC5C's role in disease may offer therapeutic insights and intervention strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
See full target information GPRC5C
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Bone 176:116866 PubMed37558192

2023

G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals.

Applications

Unspecified application

Species

Unspecified reactive species

Parisa Dashti,Roman Thaler,John R Hawse,M Lizeth Galvan,Bram J van der Eerden,Andre J van Wijnen,Amel Dudakovic

International journal of molecular sciences 24: PubMed37240083

2023

AEC and AFMSC Transplantation Preserves Fertility of Experimentally Induced Rat Varicocele by Expressing Differential Regenerative Mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Alessia Peserico,Barbara Barboni,Valentina Russo,Delia Nardinocchi,Maura Turriani,Costanza Cimini,Nicola Bernabò,Ornella Parolini,Antonietta Rosa Silini,Ivana Antonucci,Liborio Stuppia,Paolo Berardinelli,Ilaria Falanga,Davide Perruzza,Luca Valbonetti,Annunziata Mauro
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB137482

Anti-GPRC5C antibody - C-terminal

Western blot - Anti-GPRC5C antibody - C-terminal (AB137482)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB229060

Anti-CHRAC-17 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CHRAC-17 antibody (AB229060)

  • 0
  • 0
Primary Antibodies

AB75285

Anti-OPN3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-OPN3 antibody (AB75285)

  • 0
  • 0
Primary Antibodies

AB150346

Anti-Leu Enkephalin antibody [NOC1]

  • 5
  • 3
Primary Antibodies

AB271180

Rabbit monoclonal [EPR24334-118] to SARS-CoV-2 nucleocapsid protein

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Rabbit monoclonal [EPR24334-118] to SARS-CoV-2 nucleocapsid protein (AB271180)

  • 5
  • 4

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com