Rabbit Polyclonal GPX5 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link O75715
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
Target data
Function
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Alternative names
Epididymal secretory glutathione peroxidase, Epididymis-specific glutathione peroxidase-like protein, Glutathione peroxidase 5, EGLP, GPx-5, GSHPx-5, GPX5
Recommended products
Rabbit Polyclonal GPX5 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link O75715
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GPX5 also known as Glutathione Peroxidase 5 or Epididymal Secretory Glutathione Peroxidase is an antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides. It belongs to the glutathione peroxidase family and has a mass of approximately 22 kDa. GPX5 is expressed mainly in the epididymis of the male reproductive tract. It plays an important role in protecting sperm from oxidative stress by neutralizing harmful peroxides which can damage cellular structures and affect sperm functionality.
- Biological function summary
GPX5 functions to preserve the integrity of sperm cells during their maturation. By reducing oxidative stress it safeguards the membrane lipid components and essential proteins from oxidative damage. GPX5 operates independently and does not require selenium as a cofactor which differentiates it from other family members. This unique characteristic allows it to function in environments that may have varying selenium levels providing an essential antioxidant defense in sperm-rich regions.
- Pathways
GPX5 integrates into cellular antioxidant mechanisms and is involved in the reduction-oxidation (redox) homeostasis. It participates in the detoxification of peroxides alongside proteins such as catalase and other glutathione peroxidases including GPX1. The pathway interaction establishes a balance between oxidants and antioxidants maintaining cellular health and efficiency in detoxifying reactive oxygen species.
- Associated diseases and disorders
GPX5 potentially associates with male infertility due to its role in safeguarding sperm from oxidative damage. Lower activity or expression levels of GPX5 may contribute to increased oxidative stress in spermatozoa leading to impaired sperm function and reduced fertility. Additionally oxidative stress-related conditions could be linked to other proteins such as superoxide dismutases which like GPX5 play roles in reducing reactive oxygen species within reproductive tissues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPX5 antibody (ab230025)
Paraffin-embedded human liver tissue stained for GPX5 with ab230025 at 1/100 dilution in immunohistochemical analysis.
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