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AB230025

Anti-GPX5 antibody

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(1 Publication)

Rabbit Polyclonal GPX5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100.

View Alternative Names

Epididymal secretory glutathione peroxidase, Epididymis-specific glutathione peroxidase-like protein, Glutathione peroxidase 5, EGLP, GPx-5, GSHPx-5, GPX5

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPX5 antibody (AB230025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPX5 antibody (AB230025)

Paraffin-embedded human liver tissue stained for GPX5 with ab230025 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Epididymal secretory glutathione peroxidase aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O75715

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPX5 also known as Glutathione Peroxidase 5 or Epididymal Secretory Glutathione Peroxidase is an antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides. It belongs to the glutathione peroxidase family and has a mass of approximately 22 kDa. GPX5 is expressed mainly in the epididymis of the male reproductive tract. It plays an important role in protecting sperm from oxidative stress by neutralizing harmful peroxides which can damage cellular structures and affect sperm functionality.
Biological function summary

GPX5 functions to preserve the integrity of sperm cells during their maturation. By reducing oxidative stress it safeguards the membrane lipid components and essential proteins from oxidative damage. GPX5 operates independently and does not require selenium as a cofactor which differentiates it from other family members. This unique characteristic allows it to function in environments that may have varying selenium levels providing an essential antioxidant defense in sperm-rich regions.

Pathways

GPX5 integrates into cellular antioxidant mechanisms and is involved in the reduction-oxidation (redox) homeostasis. It participates in the detoxification of peroxides alongside proteins such as catalase and other glutathione peroxidases including GPX1. The pathway interaction establishes a balance between oxidants and antioxidants maintaining cellular health and efficiency in detoxifying reactive oxygen species.

GPX5 potentially associates with male infertility due to its role in safeguarding sperm from oxidative damage. Lower activity or expression levels of GPX5 may contribute to increased oxidative stress in spermatozoa leading to impaired sperm function and reduced fertility. Additionally oxidative stress-related conditions could be linked to other proteins such as superoxide dismutases which like GPX5 play roles in reducing reactive oxygen species within reproductive tissues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
See full target information Epididymal secretory glutathione peroxidase
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 12:42 PubMed33414446

2021

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress.

Applications

Unspecified application

Species

Unspecified reactive species

Susu Guo,Yuxin Chen,Yueyue Yang,Xiao Zhang,Lifang Ma,Xiangfei Xue,Yongxia Qiao,Jiayi Wang
View all publications
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