Anti-Granzyme B antibody [GZMB/2403] - BSA and Azide free
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(4 Publications)
Mouse Monoclonal Granzyme B antibody. Carrier free. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GZMB aa 50-200.
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CGL1, CSPB, CTLA1, GRB, GZMB, Granzyme B, C11, CTLA-1, Cathepsin G-like 1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, Granzyme-2, Human lymphocyte protein, SECT, T-cell serine protease 1-3E, CTSGL1, Lymphocyte protease, HLP
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granzyme B antibody [GZMB/2403] - BSA and Azide free (AB237847)
Formalin-fixed, paraffin-embedded human spleen tissue stained for Granzyme B using ab237847 at 2 μg/ml in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granzyme B antibody [GZMB/2403] - BSA and Azide free (AB237847)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for Granzyme B using ab237847 at 2 μg/ml in immunohistochemical analysis.
- Protein Array
Supplier Data
Protein Array - Anti-Granzyme B antibody [GZMB/2403] - BSA and Azide free (AB237847)
Analysis of Protein Array containing >19,000 full-length human proteins using ab237847.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
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Supplementary information
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Biological function summary
Granzyme B participates prominently in the immune response by activating caspases particularly caspase-3 which promotes the breakdown of cellular components necessary for apoptosis. Granzyme B does not function in isolation but acts in concert with other immune system factors such as perforin to effectively induce cell death. Perforin creates pores in the target cell membrane allowing granzyme B to enter and instigate the apoptosis sequence. The enzyme also contributes to the processing of cytokines which enhances the immune response further.
Pathways
Studies have determined that granzyme B is critical in the apoptosis pathway particularly in the granule exocytosis pathway. It closely interacts with proteins such as perforin and other granzymes to mediate apoptosis in target cells. Granzyme B also plays a role in the inflammatory response and can influence pathways associated with cytotoxic T cell signaling. Its pathway interactions ensure effective elimination of damaged or infected cells maintaining tissue homeostasis.
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Target data
Publications (4)
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Biomolecules 15: PubMed40563509
2025
Applications
Unspecified application
Species
Unspecified reactive species
PLoS pathogens 20:e1012768 PubMed39652618
2024
Applications
Unspecified application
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Unspecified reactive species
International journal of oral science 16:29 PubMed38622125
2024
Applications
Unspecified application
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Unspecified reactive species
Science translational medicine 13: PubMed33568521
2021
Applications
Unspecified application
Species
Unspecified reactive species
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