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AB234746

Anti-Granzyme M antibody

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(1 Publication)

Rabbit Polyclonal Granzyme M antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GZMM aa 50-250.

View Alternative Names

MET1, GZMM, Granzyme M, Met-1 serine protease, Met-ase, Natural killer cell granular protease, Hu-Met-1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Granzyme M antibody (AB234746)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Granzyme M antibody (AB234746)

MCF7 (human breast adenocarcinoma cell line) cells labeling Granzyme M (green) using ab234746 at 1/100 dilution in ICC/IF analysis. Secondary antibody is Alexa Fluor® 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granzyme M antibody (AB234746)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Granzyme M antibody (AB234746)

Paraffin-embedded human lung tissue stained for Granzyme M using ab234746 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GZMM aa 50-250. The exact immunogen used to generate this antibody is proprietary information.

P51124

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protease Granzyme M also known as EC 3.4.21.79 plays a vital role in immune function. It belongs to the serine protease family and has a molecular mass of approximately 27 kDa. Granzyme M is expressed in natural killer (NK) cells and cytotoxic T lymphocytes. These immune cells utilize Granzyme M to induce apoptosis in target cells acting as a defense mechanism against infections and tumors.
Biological function summary

The protease Granzyme M contributes to the induction of cell death. Notably it does not form part of a larger complex and acts independently. Its primary function is to cleave intracellular substrates which leads to the disintegration of target cells' structural proteins and the ultimate demise of infected or cancerous cells. While other granzymes share similar roles Granzyme M shows distinct substrate specificity which provides diversity in immune responses.

Pathways

Granzyme M functions significantly within the immune system's apoptotic pathways. It interacts indirectly with proteins such as caspases other granzymes including Granzymes A and B influencing these cell death pathways. While it does not directly cleave caspases Granzyme M helps dismantle vital cellular components facilitating further activity of caspase proteins in apoptosis.

Granzyme M exhibits connections to cancer and viral infections. Tumor cells and virally-infected cells become targets of Granzyme M's cytotoxic actions. Studies show overlapping functions among granzymes in targeting malignant cells with Granzyme M complementing other granzymes' efforts in eliminating harmful cells. Additionally its activity links to proteins like perforin which assists in delivering granzymes into target cells and heightens the immune system's response against pathological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
See full target information GZMM
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2412233 PubMed39680752

2024

SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wang Xin,Jie Zhou,Yuzhu Peng,Shuiqin Gong,Wenhao Liao,Yaqin Wang,Xixin Huang,Yang Mao,Mengying Yao,Shaozong Qin,Jiachuan Xiong,Yan Li,Qigang Lan,Yinghui Huang,Jinghong Zhao
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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