JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB270741

Anti-GREB1 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal GREB1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human GREB1 aa 600-750.

View Alternative Names

KIAA0575, GREB1, Protein GREB1, Gene regulated in breast cancer 1 protein

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)

Paraffin-embedded human placenta tissue stained for GREB1 using ab270741 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)

Paraffin-embedded human kidney tissue stained for GREB1 using ab270741 at 1/500 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-GREB1 antibody (AB270741)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GREB1 antibody (AB270741)

Immunofluorescence analysis of human MCF7 cells labeling GREB1 using ab270741 at 2 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)

Paraffin-embedded human endometrium tissue stained for GREB1 using ab270741 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GREB1 antibody (AB270741)

Paraffin-embedded human skin tissue stained for GREB1 using ab270741 at 1/500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GREB1 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.

Q4ZG55

style
left-column

Complementary Products

Primary Antibodies

AB255610

Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10] (AB255610)

  • 5
  • 2
Primary Antibodies

AB108339

Anti-CD168 antibody [EPR4055]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD168 antibody [EPR4055] (AB108339)

  • 0
  • 0
Primary Antibodies

AB262879

Anti-ZRANB1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZRANB1 antibody (AB262879)

  • 0
  • 0
Primary Antibodies

AB109287

Anti-KAP1 antibody [EPR5216]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAP1 antibody [EPR5216] (AB109287)

  • 5
  • 4
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Purification notes
Used the PrEST antigen as affinity ligand.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GREB1 also known as growth regulation by estrogen in breast cancer 1 is a protein with a molecular mass of approximately 216 kDa. This protein is composed of various structural domains that facilitate its interaction with other biomolecules. GREB1 expression mainly occurs in hormone-responsive tissues including breast and prostate tissues and it has been detected in other tissues as well. The regulation of GREB1 expression is known to be tightly controlled by estrogen signals making it an essential component in estrogen-related pathways.
Biological function summary

GREB1 plays a significant role in cell proliferation and differentiation within estrogen-dependent systems. This function connects it to critical physiological processes. GREB1 acts as an estrogen-responsive gene supporting its involvement in cellular growth mechanisms. It functions as part of a larger complex of proteins mediating signals essential for growth particularly in the context of reproductive biology. Its functionality in these processes highlights its relevance in the study of hormonal regulation.

Pathways

GREB1 integrates into the estrogen receptor signaling pathway as well as the PI3K/Akt pathway. These pathways are key in the regulation of cell survival and proliferation. GREB1 interacts with other proteins such as estrogen receptor alpha (ERα) within these signaling cascades reinforcing its function as an essential modulator of cellular responses to hormonal signals. This integration illustrates the broader network of interactions that GREB1 engages with in cellular environments influencing pathophysiological outcomes.

GREB1 is strongly linked to breast cancer and prostate cancer both of which depend on hormonal dynamics for their development and progression. In the case of breast cancer GREB1 operates alongside proteins like the androgen receptor and ERα reflecting its role in tumor growth that is sensitive to hormonal regulation. Understanding GREB1's contribution to these cancers contributes to developing targeted therapeutic approaches highlighting the importance of this protein in clinical oncology research.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
See full target information GREB1
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com