AB22138

Anti-Gremlin 1 antibody

Name: Anti-Gremlin 1 antibody (ab22138) | Abcam
Brand: Abcam Limited
SKU: AB22138

Be the first to review this product! Submit a review

(10 Publications)

Rabbit Polyclonal Gremlin 1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human GREM1 aa 50-100.

View Alternative Names

CKTSF1B1, DAND2, DRM, PIG2, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gremlin 1 antibody (AB22138)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gremlin 1 antibody (AB22138)

Detection of Gremlin 1 in human colon cancer tissue using ab22138 at 5 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GREM1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

O60565

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Gremlin 1 often referred to as Gremlin or gremlin-1 protein acts as an antagonist to bone morphogenetic proteins (BMPs). Commonly known as Gremlin 1 protein or Gremlin rat in certain studies it exhibits a mass of approximately 28 kDa. Researchers find Gremlin 1 expressed in various tissues including the kidney lung and limb bud highlighting its presence in numerous developmental processes. Its presence in these tissues indicates its importance in organogenesis and tissue differentiation.

Biological function summary

Gremlin 1 inhibits the BMP pathway which plays an important role in cellular growth and differentiation. It does not function alone; instead it becomes part of a complex interaction network that modulates cell proliferation and embryonic organ development. Gremlin 1's binding to BMPs prevents them from interacting with their receptors affecting the signaling cascade necessary for normal bone and cartilage development as well as vascular patterning.

Pathways

The regulatory function of Gremlin 1 is essential in the BMP signaling pathway. The well-known TGF-beta signaling pathway is influenced by Gremlin 1 as it regulates the balance of BMP activity. Gremlin 1's interaction with BMP4 a closely related protein exemplifies its impact on the differentiation and proliferation of mesenchymal cells.

Gremlin 1 expression has links to fibrotic diseases such as pulmonary fibrosis and chronic kidney disease. These conditions often involve excessive tissue scarring and dysfunction where Gremlin 1's modulation of the BMP pathway exacerbates the fibrosis process. Additionally its interaction with proteins such as BMP7 during these disease states highlights the potential for therapeutic targeting to reverse or inhibit fibrotic progression.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed : 27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).

See full target information GREM1

style

left-column

Publications (10)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39125809

2024

Expression of Osteopontin and Gremlin 1 Proteins in Cardiomyocytes in Ischemic Heart Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Milda Kuprytė,Vaiva Lesauskaitė,Vitalija Siratavičiūtė,Lina Utkienė,Lina Jusienė,Dalia Pangonytė

Frontiers in oncology 13:1249172 PubMed38045001

2023

Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Verena Maria Raters,Florian Gebauer,Heike Löser,Wolfgang Schröder,Hans Anton Schlösser,Hans Fuchs,Christiane Bruns,Alexander Quaas,Thomas Zander

Stem cells international 2021:8833527 PubMed33953754

2021

NAT10 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Mediating N4-Acetylcytidine Modification of Gremlin 1.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenbiao Zhu,Xiaowei Xing,Shisi Huang,Yuanyuan Tu

Journal of cellular and molecular medicine : PubMed33107676

2020

Role of miR-218-GREM1 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma: An in vivo and vitro study based on microarray data.

Applications

Unspecified application

Species

Unspecified reactive species

Yanpeng Wang,Yifeng Jiang,Long Chen

Pathology oncology research : POR 26:2509-2521 PubMed32583331

2020

Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin Marquet,Aude Marchal Bressenot,Caroline Fichel,Nicole Bouland,Coralie Barbe,Olivier Bouché,Reza Kianmanesh,Marie-Danièle Diebold,Camille Boulagnon-Rombi

Cancer cell international 19:147 PubMed31143092

2019

Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial-mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Miao,Nuan Wang,Lin-Xin Shi,Zheng Wang,Wen-Bo Song

International journal of oncology 53:2445-2457 PubMed30272371

2018

Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Yongtian Yu,Liang Cheng,Bin Yan,Cancan Zhou,Weikun Qian,Ying Xiao,Tao Qin,Junyu Cao,Liang Han,Qingyong Ma,Jiguang Ma

Cellular physiology and biochemistry : internation 47:1785-1799 PubMed29953975

2018

Gremlin1 Delivered by Mesenchymal Stromal Cells Promoted Epithelial-Mesenchymal Transition in Human Esophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dongxi Hong,Te Liu,Weijun Huang,Yan Liao,Lin Wang,Zhen Zhang,Haixuan Chen,Xinchun Zhang,Qiuling Xiang

Anticancer research 38:1419-1425 PubMed29491067

2018

Clinicopathological and Prognostic Significance of Epithelial Gremlin1 Expression in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ririno Honma,Naoya Sakamoto,Akira Ishikawa,Daiki Taniyama,Kaho Fukada,Takuya Hattori,Kazuhiro Sentani,Naohide Oue,Kazuaki Tanabe,Hideki Ohdan,Wataru Yasui

Histopathology 69:831-838 PubMed27257976

2016

Gremlin1 expression associates with serrated pathway and favourable prognosis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ari Pelli,Juha P Väyrynen,Kai Klintrup,Jyrki Mäkelä,Markus J Mäkinen,Anne Tuomisto,Tuomo J Karttunen

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Gremlin 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gremlin 1 antibody (AB22138)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

Product promise