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AB155604

Anti-GRHPR antibody

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(1 Publication)

Rabbit Polyclonal GRHPR antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRHPR aa 1-350.

View Alternative Names

GLXR, MSTP035, GRHPR, Glyoxylate reductase/hydroxypyruvate reductase

2 Images
Western blot - Anti-GRHPR antibody (AB155604)
  • WB

Unknown

Western blot - Anti-GRHPR antibody (AB155604)

10% SDS PAGE

All lanes:

Western blot - Anti-GRHPR antibody (ab155604) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 36 kDa

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Western blot - Anti-GRHPR antibody (AB155604)
  • WB

Unknown

Western blot - Anti-GRHPR antibody (AB155604)

10% SDS PAGE

All lanes:

Western blot - Anti-GRHPR antibody (ab155604) at 1/10000 dilution

All lanes:

Mouse liver whole cell lysate at 20 µg

Predicted band size: 36 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human GRHPR aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q9UBQ7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GRHPR also called glyoxylate reductase/hydroxypyruvate reductase is an enzyme with mass about 35 kDa. It catalyzes the conversion of glyoxylate to glycolate and hydroxypyruvate to D-glycerate. This protein exists in the cytoplasm and is found in tissues like liver kidney and pancreas. Its enzymatic activity plays a role in regulating the balance between glyoxylate and glycolate within cells.
Biological function summary

GRHPR acts as a detoxifying agent by reducing glyoxylate levels protecting cells from glyoxylate-mediated toxicity. This enzyme is not part of a larger complex and functions independently. Well-balanced glyoxylate and glycolate levels are critical for cellular homeostasis and GRHPR ensures proper maintenance and regulation within metabolic pathways.

Pathways

GRHPR participates in glyoxylate and dicarboxylate metabolism helping control the flow of metabolites. This involvement is significant in the context of the glyoxylate cycle and serine metabolism. Additionally it interacts with proteins such as lactate dehydrogenase during its activity within these metabolic pathways demonstrating its interconnectedness within cellular processes.

GRHPR mutations are associated with primary hyperoxaluria type 2 a disorder characterized by excessive oxalate production leading to kidney stones. In this context GRHPR dysfunction can lead to increased glyoxylate levels causing elevated oxalate synthesis. The enzyme's connection to this disease is critical as it is one of the few proteins whose dysfunction directly results in the metabolic imbalance observed in primary hyperoxaluria type 2.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate.
See full target information GRHPR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Toxicology letters 243:98-110 PubMed26739637

2016

Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Philip M Probert,Jeremy M Palmer,Wasma Alhusainy,Aimen O Amer,Ivonne M C M Rietjens,Steven A White,David E Jones,Matthew C Wright
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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