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AB183035

Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726]

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(1 Publication)

Rabbit Recombinant Monoclonal GRIK3/GluK3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

GLUR7, GRIK3, GluK3, Excitatory amino acid receptor 5, Glutamate receptor 7, EAA5, GluR-7, GluR7

2 Images
Western blot - Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] (AB183035)
  • WB

Supplier Data

Western blot - Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] (AB183035)

All lanes:

Western blot - Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] (ab183035) at 1/5000 dilution

All lanes:

Human cerebellum cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-rabbit IgG HRP at 1/1000 dilution

Predicted band size: 104 kDa

false

Western blot - Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] (AB183035)
  • WB

Supplier Data

Western blot - Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] (AB183035)

All lanes:

Western blot - Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] (ab183035) at 1/1000 dilution

All lanes:

Human hippocampus cell lysate at 20 µg

Secondary

All lanes:

Gaot Anti-rabbit IgG HRP at 1/1000 dilution

Predicted band size: 104 kDa

false

  • Carrier free

    Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13726

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GRIK2 and GRIK3 also known as GluK2 and GluK3 are ionotropic receptors that facilitate synaptic transmission in the central nervous system. They are part of the kainate receptor family which operates by binding the neurotransmitter glutamate. The molecular mass for GluK2 is approximately 98 kDa while GluK3 is similar in size. These receptors predominantly localize in the brain particularly in the hippocampus and cerebellum where they play significant roles in excitatory neurotransmission.
Biological function summary

GRIK2 and GRIK3 function as part of ligand-gated ion channels which regulate the flow of ions across the cell membrane upon activation by glutamate. They contribute to forming heteromeric receptor complexes with other kainate receptor subunits. Such complexes are critical in modulating synaptic plasticity and neuronal excitability influencing learning and memory processes.

Pathways

GRIK2 and GRIK3 engage in the glutamatergic synapse pathway. This pathway involves critical proteins like AMPA and NMDA receptors which also bind glutamate and contribute to synaptic transmission and plasticity. The receptors assist in maintaining the balance of excitation and inhibition in neuronal networks playing important roles in both normal physiology and response to neurotransmitter fluctuations.

GRIK2 and GRIK3 have associations with neurological conditions such as epilepsy and schizophrenia. Their altered function or expression can disrupt synaptic transmission leading to abnormal neuronal excitability and network dysfunction. They interact with NMDA receptors further affecting glutamatergic signaling in these diseases potentially serving as targets for therapeutic intervention strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed : 7719709). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity).
See full target information GRIK3

Additional targets

GRIK2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 20:266-274 PubMed32565953

2020

Hsa_circ_0038646 promotes cell proliferation and migration in colorectal cancer via miR-331-3p/GRIK3.

Applications

Unspecified application

Species

Unspecified reactive species

Haipeng Du,Zhiguo He,Fumei Feng,Daming Chen,Lei Zhang,Jingzhen Bai,Huiguo Wu,Enkun Han,Jiansheng Zhang
View all publications
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Product promise

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