Anti-GRIK2/GluK2 + GRIK3/GluK3 antibody [EPR13726] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GRIK2 and GRIK3 also known as GluK2 and GluK3 are ionotropic receptors that facilitate synaptic transmission in the central nervous system. They are part of the kainate receptor family which operates by binding the neurotransmitter glutamate. The molecular mass for GluK2 is approximately 98 kDa while GluK3 is similar in size. These receptors predominantly localize in the brain particularly in the hippocampus and cerebellum where they play significant roles in excitatory neurotransmission.

Biological function summary

GRIK2 and GRIK3 function as part of ligand-gated ion channels which regulate the flow of ions across the cell membrane upon activation by glutamate. They contribute to forming heteromeric receptor complexes with other kainate receptor subunits. Such complexes are critical in modulating synaptic plasticity and neuronal excitability influencing learning and memory processes.

Pathways

GRIK2 and GRIK3 engage in the glutamatergic synapse pathway. This pathway involves critical proteins like AMPA and NMDA receptors which also bind glutamate and contribute to synaptic transmission and plasticity. The receptors assist in maintaining the balance of excitation and inhibition in neuronal networks playing important roles in both normal physiology and response to neurotransmitter fluctuations.

Associated diseases and disorders

GRIK2 and GRIK3 have associations with neurological conditions such as epilepsy and schizophrenia. Their altered function or expression can disrupt synaptic transmission leading to abnormal neuronal excitability and network dysfunction. They interact with NMDA receptors further affecting glutamatergic signaling in these diseases potentially serving as targets for therapeutic intervention strategies.