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AB222150

Anti-GRIN1 antibody

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(1 Publication)

Rabbit Polyclonal GRIN1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GPRIN1 aa 400-550.

View Alternative Names

KIAA1893, GPRIN1, G protein-regulated inducer of neurite outgrowth 1, GRIN1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-GRIN1 antibody (AB222150)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GRIN1 antibody (AB222150)

PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for GRIN1 (green) using ab222150 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIN1 antibody (AB222150)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIN1 antibody (AB222150)

Paraffin-embedded human caudate tissue stained for GRIN1 with ab222150 at 1/2500 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GPRIN1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q7Z2K8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2500 - 1/5000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GRIN1 also known as GluN1 represents a subunit of the NMDA receptor essential for normal synaptic function. This receptor weighs approximately 120 kDa and is mainly expressed in the brain where it plays an important role in excitatory neurotransmission. The receptor channels calcium sodium and potassium ions maintaining communication between neurons. GRIN1 combines with other subunits to form a functional receptor complex critical in mediating synaptic plasticity and memory function.
Biological function summary

GRIN1 binds with other NMDA receptor subunits to form a ligand-gated ion channel complex. The channel opens in response to glutamate binding allowing ions to flow through the membrane. This activity is fundamental for synaptic plasticity impacting processes like learning and memory. GRIN1 modulation affects activities at the synapse influencing both neuronal survival and excitatory signaling.

Pathways

NMDA receptors involving GRIN1 participate in the glutamatergic neurotransmission pathway which is critical for excitatory synaptic transmission. These receptors associate with proteins like CaMKII linking them to the calcium signaling pathway. The proper functioning of this pathway is important for synaptic strength and development as dysregulation can lead to neurological issues.

Aberrations in GRIN1 activity relate to neurodegenerative and psychiatric disorders. Alzheimer's disease often shows disrupted NMDA receptor function where GRIN1 plays a role in amyloid-beta-mediated neuronal damage. Moreover dysregulation of GRIN1 is connected to schizophrenia where abnormal synaptic signaling alters brain function. Both diseases underline the importance of proper GRIN1 function in maintaining neural health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in neurite outgrowth.
See full target information GPRIN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Science advances 10:eadk8908 PubMed38781342

2024

CK2-dependent degradation of CBX3 dictates replication fork stalling and PARP inhibitor sensitivity.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Ma,Dianyun Ren,Zixi Wang,Wei Li,Lei Li,Tianjie Liu,Qi Ye,Yuzeshi Lei,Yanlin Jian,Bohan Ma,Yizeng Fan,Jing Liu,Yang Gao,Xin Jin,Haojie Huang,Lei Li
View all publications
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Product promise

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