Anti-GRIN1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GRIN1 also known as GluN1 represents a subunit of the NMDA receptor essential for normal synaptic function. This receptor weighs approximately 120 kDa and is mainly expressed in the brain where it plays an important role in excitatory neurotransmission. The receptor channels calcium sodium and potassium ions maintaining communication between neurons. GRIN1 combines with other subunits to form a functional receptor complex critical in mediating synaptic plasticity and memory function.

Biological function summary

GRIN1 binds with other NMDA receptor subunits to form a ligand-gated ion channel complex. The channel opens in response to glutamate binding allowing ions to flow through the membrane. This activity is fundamental for synaptic plasticity impacting processes like learning and memory. GRIN1 modulation affects activities at the synapse influencing both neuronal survival and excitatory signaling.

Pathways

NMDA receptors involving GRIN1 participate in the glutamatergic neurotransmission pathway which is critical for excitatory synaptic transmission. These receptors associate with proteins like CaMKII linking them to the calcium signaling pathway. The proper functioning of this pathway is important for synaptic strength and development as dysregulation can lead to neurological issues.

Associated diseases and disorders

Aberrations in GRIN1 activity relate to neurodegenerative and psychiatric disorders. Alzheimer's disease often shows disrupted NMDA receptor function where GRIN1 plays a role in amyloid-beta-mediated neuronal damage. Moreover dysregulation of GRIN1 is connected to schizophrenia where abnormal synaptic signaling alters brain function. Both diseases underline the importance of proper GRIN1 function in maintaining neural health.