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AB74577

Anti-GRIN1 antibody

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(1 Publication)

Rabbit Polyclonal GRIN1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GPRIN1.

View Alternative Names

KIAA1893, GPRIN1, G protein-regulated inducer of neurite outgrowth 1, GRIN1

1 Images
Western blot - Anti-GRIN1 antibody (AB74577)
  • WB

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Western blot - Anti-GRIN1 antibody (AB74577)

All lanes:

Western blot - Anti-GRIN1 antibody (ab74577) at 1/500 dilution

Lane 1:

HT29 cell extracts at 10 µg

Lane 2:

HT29 cell extracts at 10 µg with immunising peptide

Predicted band size: 102 kDa

Observed band size: 102 kDa,20 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human GPRIN1. The exact immunogen used to generate this antibody is proprietary information.

Q7Z2K8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab74577 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GRIN1 also known as GluN1 represents a subunit of the NMDA receptor essential for normal synaptic function. This receptor weighs approximately 120 kDa and is mainly expressed in the brain where it plays an important role in excitatory neurotransmission. The receptor channels calcium sodium and potassium ions maintaining communication between neurons. GRIN1 combines with other subunits to form a functional receptor complex critical in mediating synaptic plasticity and memory function.
Biological function summary

GRIN1 binds with other NMDA receptor subunits to form a ligand-gated ion channel complex. The channel opens in response to glutamate binding allowing ions to flow through the membrane. This activity is fundamental for synaptic plasticity impacting processes like learning and memory. GRIN1 modulation affects activities at the synapse influencing both neuronal survival and excitatory signaling.

Pathways

NMDA receptors involving GRIN1 participate in the glutamatergic neurotransmission pathway which is critical for excitatory synaptic transmission. These receptors associate with proteins like CaMKII linking them to the calcium signaling pathway. The proper functioning of this pathway is important for synaptic strength and development as dysregulation can lead to neurological issues.

Aberrations in GRIN1 activity relate to neurodegenerative and psychiatric disorders. Alzheimer's disease often shows disrupted NMDA receptor function where GRIN1 plays a role in amyloid-beta-mediated neuronal damage. Moreover dysregulation of GRIN1 is connected to schizophrenia where abnormal synaptic signaling alters brain function. Both diseases underline the importance of proper GRIN1 function in maintaining neural health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in neurite outgrowth.
See full target information GPRIN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 14:4119-4123 PubMed27667392

2016

Dysregulation of GTPase IMAP family members in hepatocellular cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Huang,Wei Zhang,Chunhai Gao,Baoju Ji,Xiuwen Chi,Wei Zheng,Hai Lan Wang
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