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AB113427

Anti-GRINL1A antibody

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(1 Publication)

Rabbit Polyclonal GRINL1A antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human POLR2M.

View Alternative Names

GRINL1A, POLR2M, DNA-directed RNA polymerase II subunit GRINL1A, DNA-directed RNA polymerase II subunit M, Glutamate receptor-like protein 1A

1 Images
Western blot - Anti-GRINL1A antibody (AB113427)
  • WB

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Western blot - Anti-GRINL1A antibody (AB113427)

Lane 1:

Western blot - Anti-GRINL1A antibody (ab113427) at 1 µg/mL

Lane 2:

Western blot - Anti-GRINL1A antibody (ab113427) at 2 µg/mL

All lanes:

Rat Kidney lysate at 15 µg

Predicted band size: 42 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human POLR2M. The exact immunogen used to generate this antibody is proprietary information.

P0CAP2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GRINL1A also known as NMDAR-like protein 1A is a protein of interest in the study of cellular function. It weighs approximately 118 kDa and has been identified in various tissues including the brain. Researchers have suggested that GRINL1A influences ion channel regulation which is key in maintaining cellular excitability and synaptic transmission. The protein exhibits distinct expression across neurons indicating a significant role in neural activity and connectivity.
Biological function summary

GRINL1A interacts closely with the NMDA receptor complex a significant player in synaptic plasticity and memory formation. By modulating this receptor complex GRINL1A impacts calcium ion influx into the neuron which is necessary for activating intracellular signaling pathways. Studies have shown that it adjusts the NMDA receptor's sensitivity impacting long-term potentiation and learning processes.

Pathways

GRINL1A functions within the glutamatergic signaling pathway and influences neuron communication by modulating excitatory neurotransmission. The protein is functionally related to the NMDA receptor subunits such as NR1 and NR2. This interaction is essential for activity-dependent synaptic strengthening and is pivotal in the process of synaptic plasticity linking GRINL1A to cognitive function and adaptation to neural changes.

Researchers associate GRINL1A with neurodegenerative conditions like Alzheimer's disease and neurological disorders like schizophrenia. Its connection with the NMDA receptor complex implicates GRINL1A in these conditions as altered glutamatergic signaling often underlies their pathology. GRINL1A's regulation of NMDA receptors also connects it to proteins such as PSD-95 which plays a role in synaptic stability and cognitive impairment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
See full target information POLR2M
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

CytoJournal 21:77 PubMed39917007

2025

Investigating the role of exosomal microRNA-5703 in modulating tumor-associated endothelial cells in lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Bing Wen,Rancen Tao,Yuyu Liu,Zhenfa Zhang
View all publications
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