Rabbit Polyclonal GRIP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRIP1 aa 800-900.
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- PloS one 10:e01175812015Discovery of molecular markers to discriminate corneal endothelial cells in the human body.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMasahito Yoshihara et. al.PubMed 25807145
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human GRIP1 aa 800-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y3R0
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Use buffer at pH 6 for antigen retrieval. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
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Target data
Function
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Alternative names
Glutamate receptor-interacting protein 1, GRIP-1, GRIP1
Recommended products
Rabbit Polyclonal GRIP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRIP1 aa 800-900.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human GRIP1 aa 800-900. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y3R0
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Notes
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GRIP1 also known as Glutamate Receptor Interacting Protein 1 is a protein that serves as a scaffold for various cellular signaling molecules. It weighs approximately 127 kDa. GRIP1 is expressed mainly in the central nervous system where it interacts with membrane proteins to facilitate their proper localization and function. It supports the clustering and stabilization of AMPA receptors at synaptic sites which is essential for synaptic transmission and plasticity.
- Biological function summary
GRIP1 plays a role in synaptic formation and maintenance. It is a part of a multi-protein complex that influences the trafficking and stabilization of AMPA-type glutamate receptors. By regulating these receptors it contributes to synaptic plasticity a process fundamental for learning and memory. Additionally GRIP1 interacts with proteins like GRASP and liprin-α which further regulate synaptic density and neural connectivity.
- Pathways
GRIP1 is involved in synaptic signaling pathways and neuronal communication. It participates in the maintenance of long-term potentiation (LTP) an activity-dependent strengthening of synapses that is central to memory and learning. GRIP1 interacts closely with proteins like GRASP1 and PICK1 in these pathways. These interactions are critical for mediating changes in synaptic strength and receptor turnover that underpin neural plasticity.
- Associated diseases and disorders
GRIP1's dysregulation associates with neuropsychiatric conditions such as autism spectrum disorder (ASD) and schizophrenia. Alterations in GRIP1 function can affect AMPA receptor trafficking impacting synaptic efficiency and cognitive function. In ASD GRIP1 connects with the protein SHANK3 influencing synapse functionality and neuronal development. In schizophrenia irregularities in GRIP1 contribute to synaptic dysfunction linking it to a broader network of proteins impacting glutamate signaling.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (ab122514)
ab122514 at 1/75 dilution staining GRIP1 in Paraffin-embedded Human Pancreas tissue by Immunohistochemistry.
Note: strong cytoplasmic positivity in exocrine pancreas.
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