AB122514

Anti-GRIP1 antibody

Name: Anti-GRIP1 antibody (ab122514) | Abcam
Brand: Abcam Limited
SKU: AB122514
Price: 645 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal GRIP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRIP1 aa 800-900.

View Alternative Names

Glutamate receptor-interacting protein 1, GRIP-1, GRIP1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (AB122514)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (AB122514)

ab122514 at 1/75 dilution staining GRIP1 in Paraffin-embedded Human Pancreas tissue by Immunohistochemistry.
Note : strong cytoplasmic positivity in exocrine pancreas.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human GRIP1 aa 800-900. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3R0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p>Use buffer at pH 6 for antigen retrieval.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GRIP1 also known as Glutamate Receptor Interacting Protein 1 is a protein that serves as a scaffold for various cellular signaling molecules. It weighs approximately 127 kDa. GRIP1 is expressed mainly in the central nervous system where it interacts with membrane proteins to facilitate their proper localization and function. It supports the clustering and stabilization of AMPA receptors at synaptic sites which is essential for synaptic transmission and plasticity.

Biological function summary

GRIP1 plays a role in synaptic formation and maintenance. It is a part of a multi-protein complex that influences the trafficking and stabilization of AMPA-type glutamate receptors. By regulating these receptors it contributes to synaptic plasticity a process fundamental for learning and memory. Additionally GRIP1 interacts with proteins like GRASP and liprin-α which further regulate synaptic density and neural connectivity.

Pathways

GRIP1 is involved in synaptic signaling pathways and neuronal communication. It participates in the maintenance of long-term potentiation (LTP) an activity-dependent strengthening of synapses that is central to memory and learning. GRIP1 interacts closely with proteins like GRASP1 and PICK1 in these pathways. These interactions are critical for mediating changes in synaptic strength and receptor turnover that underpin neural plasticity.

GRIP1's dysregulation associates with neuropsychiatric conditions such as autism spectrum disorder (ASD) and schizophrenia. Alterations in GRIP1 function can affect AMPA receptor trafficking impacting synaptic efficiency and cognitive function. In ASD GRIP1 connects with the protein SHANK3 influencing synapse functionality and neuronal development. In schizophrenia irregularities in GRIP1 contribute to synaptic dysfunction linking it to a broader network of proteins impacting glutamate signaling.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed : 10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

See full target information GRIP1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 10:e0117581 PubMed25807145

2015

Discovery of molecular markers to discriminate corneal endothelial cells in the human body.

Applications

Unspecified application

Species

Unspecified reactive species

Masahito Yoshihara,Hiroko Ohmiya,Susumu Hara,Satoshi Kawasaki,Yoshihide Hayashizaki,Masayoshi Itoh,Hideya Kawaji,Motokazu Tsujikawa,Kohji Nishida

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GRIP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRIP1 antibody (AB122514)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise