Anti-GRO alpha + GRO gamma + GRO beta antibody [EPR4902]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The CXCL1 protein also known as GRO alpha GRO gamma and GRO beta functions as a chemokine involved in the recruitment and activation of neutrophils. The different variants share structural similarities though they have distinct biological effects. It weighs approximately 11 kDa. This target expresses in various tissues with high presence in epithelial cells and endothelial cells as well as in cells of the immune system. Its expression can be highly regulated in response to inflammatory stimuli and it can increase during immune responses.

Biological function summary

This target contributes to inflammation by attracting neutrophils to sites of tissue injury and infection aiding in the immune defense. It does not work as part of a larger complex but it can interact directly with G-protein coupled receptors on leukocytes. These interactions result in the activation of signaling pathways that lead to cell migration and proliferation supporting wound healing and tissue repair processes.

Pathways

CXCL1 is an important player in the chemokine signaling pathway where it interacts with the CXCR2 receptor triggering intracellular signaling cascades. It plays an instrumental role in the NF-kB pathway which regulates the expression of various downstream inflammatory mediators. This chemokine aligns functionally with other CXC chemokines like IL-8 sharing receptor binding to induce similar downstream effects that perpetuate inflammatory responses.

Associated diseases and disorders

CXCL1 implicates in conditions such as chronic inflammation and cancer. Its overexpression can contribute to pathologies like rheumatoid arthritis where it perpetuates joint inflammation and helps sustain the inflammatory environment. Additionally elevated levels of CXCL1 may also exacerbate tumor progression and metastasis in certain cancers by promoting angiogenesis. In these disease contexts CXCL1 interacts with other inflammatory cytokines like TNF-alpha and IL-1 which together magnify the inflammatory or oncogenic signals.