Anti-groES antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The groES protein functions within a chaperonin complex alongside groEL to prevent aggregation and promote proper protein folding. This complex plays a significant role in cellular stress response and stabilization of proteins especially under heat shock conditions. The chaperonin system refolds denatured proteins and maintains proteostasis ensuring efficient cellular function. The groES and groEL interaction facilitates timed ATP hydrolysis which is necessary for the release of correctly folded proteins back into the cellular environment.

Pathways

GroES integrates into cellular stress response and protein quality control pathways. It is important in the protein processing pathway alongside groEL and Hsp70 enabling effective folding of nascent polypeptides. GroES and these chaperones serve as emergency machinery to protect the cell during adverse conditions such as thermal or oxidative stress. Together they prevent cellular damage caused by protein misfolding which may otherwise lead to cytotoxicity or cell death.