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AB198007

Anti-Growth hormone antibody

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(2 Publications)

Rabbit Polyclonal Growth hormone antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications.

View Alternative Names

Growth hormone variant, GH-V, Growth hormone 2, Placenta-specific growth hormone, GH2, GH2, GHL, GHV, GH 2, GH V, GHB2, hGHV, hGH V, Growth hormone 2, Growth hormone B2, Growth hormone variant, Placenta specific growth hormone, Placental specific growth hormone

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth hormone antibody (AB198007)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth hormone antibody (AB198007)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling Growth hormone with ab198007 at a 1/40 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Anti-Growth Hormone antibody [GH-2]

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Complementary Products

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Growth hormone also known as somatotropin is a protein hormone with a molecular mass of approximately 22 kDa. It is synthesized and secreted by the somatotroph cells located in the anterior pituitary gland. Growth hormone functions by binding to specific receptors on target cells initiating a cascade of intracellular signaling. These signaling pathways primarily involve the JAK-STAT pathway. Growth hormone stimulates liver cells to produce insulin-like growth factor 1 (IGF-1) which mediates the majority of the growth-promoting effects.
Biological function summary

Growth hormone plays a critical role in growth metabolism and cellular regeneration. It stimulates protein synthesis increases muscle mass and promotes lipolysis affecting body composition. It is part of the growth hormone/IGF-1 axis a complex system that includes various hormones receptors and binding proteins. Growth hormone influences metabolism by enhancing glycogenolysis in the liver and reducing insulin sensitivity affecting carbohydrate metabolism. This hormone demonstrates significant anabolic effects important during childhood and adolescence as well as maintaining tissue and organ function in adults.

Pathways

Growth hormone operates within the growth hormone signaling pathway and the MAPK/ERK pathway. These pathways connect growth hormone activity to metabolic regulation and cellular growth processes. Growth hormone closely interacts with IGF-1 in these pathways where IGF-1 acts as a mediator of growth hormone's effects on growth and development. Growth hormone also affects insulin metabolism and interacts with proteins like insulin receptor substrates during these processes.

Growth hormone deficiency and acromegaly illustrate the target's impact. Growth hormone deficiency affects growth and metabolic health often resulting in dwarfism and metabolic syndrome due to insufficient production. Acromegaly caused by excess growth hormone secretion leads to abnormal tissue growth. Both conditions involve IGF-1 as an important player for either reduced or excessive production influencing disease pathology. Understanding the growth hormone's role helps in the development of therapeutic interventions targeted at these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
See full target information Growth hormone variant

Additional targets

Growth hormone
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 7:8649 PubMed28819306

2017

Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dongjun Jeong,Seona Ban,Seunghyun Oh,Su Jin Lee,Seong Yong Park,Young Wha Koh

American journal of obstetrics and gynecology 217:200.e1-200.e17 PubMed28347715

2017

Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew Gormley,Katherine Ona,Mirhan Kapidzic,Tamara Garrido-Gomez,Tamara Zdravkovic,Susan J Fisher
View all publications
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Product promise

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