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AB106630

Anti-GSAP antibody

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(6 Publications)

Rabbit Polyclonal GSAP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human GSAP.

View Alternative Names

PION, GSAP, Gamma-secretase-activating protein, Protein pigeon homolog

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSAP antibody (AB106630)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSAP antibody (AB106630)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of mouse brain tissue staining GSAP with ab106630 at 20μg/ml

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSAP antibody (AB106630)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSAP antibody (AB106630)

Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse brain tissue labeling GSAP with Anti-GSAP antibody (ab106630) at 5μg/ml.

Western blot - Anti-GSAP antibody (AB106630)
  • WB

Unknown

Western blot - Anti-GSAP antibody (AB106630)

All lanes:

Western blot - Anti-GSAP antibody (ab106630) at 0.25 µg/mL

Lane 1:

EL4 cell lysate at 15 µg

Lane 2:

EL4 cell lysate at 15 µg with blocking peptide

Predicted band size: 97 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human GSAP. The exact immunogen used to generate this antibody is proprietary information.

A4D1B5

Specificity

ab106630 is predicted to not cross-react with other F-box protein family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab106630 was purified by affinity chromatography via a peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Gamma-secretase activating protein (GSAP) is a critical regulator in the modulation of gamma-secretase activity influencing the production of amyloid beta-peptides. Also known by its alternative name GSAP the protein has a molecular mass of approximately 16 kDa. It is expressed in multiple tissues including the brain where its presence is significant due to its involvement in neurobiological processes.
Biological function summary

GSAP interacts mechanically with gamma-secretase and enhances its specificity for amyloid precursor protein (APP). This interaction plays a significant role in amyloidogenic processes and is part of a larger complex impacting the generation of amyloid beta-peptides. Through this interaction GSAP becomes an important factor in the regulation of pathways related to amyloid beta generation.

Pathways

GSAP actively participates in the amyloidogenic pathway which is pivotal in Alzheimer's disease pathology. In the context of this pathway GSAP closely interacts with gamma-secretase complex components including presenilins which significantly influence beta-amyloid levels. Likewise GSAP's interaction with APP reflects on its integral role in modulating the proteolytic cascade that generates beta-amyloid peptides.

GSAP's role is most notably linked to Alzheimer's disease. Its contribution to the production of beta-amyloid peptides positions it centrally in the pathogenesis of Alzheimer's wherein these peptides aggregate to form neurotoxic plaques. The interaction with presenilin proteins further ties GSAP to familial forms of Alzheimer's disease reinforcing its potential as a therapeutic target in mitigating such neurodegenerative disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
See full target information GSAP
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Acta histochemica et cytochemica 58:45-57 PubMed40535470

2025

Calmodulin-Like Protein 5 (CALML5) Expression in Squamous Cell Carcinoma of Esophagus and Oropharynx.

Applications

Unspecified application

Species

Unspecified reactive species

Mashio Taniwaki,Riko Kitazawa,Ryuma Haraguchi,Teruyuki Ono,Yuki Takaoka,Sohei Kitazawa

ACS omega 8:13435-13443 PubMed37065030

2023

To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides.

Applications

Unspecified application

Species

Unspecified reactive species

Deekshi Angira,Sonali Chaudhary,Arumugam Abiramasundari,Vijay Thiruvenkatam

Frontiers in oncology 12:977251 PubMed36727078

2023

Integrated analysis of genome-wide DNA methylation and cancer-associated fibroblasts identified prognostic biomarkers and immune checkpoint blockade in lower grade gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawei Dong,Fang Wang,Xin Gao,Hongtao Zhao,Jiheng Zhang,Nan Wang,Zhihui Liu,Xiuwei Yan,Jiaqi Jin,Yixu Ba,Shuai Ma,Jianyang Du,Hang Ji,Shaoshan Hu

Proceedings of the National Academy of Sciences of the United States of America 119:e2122292119 PubMed35298330

2022

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Jin,Jiaoni Wang,Yumeng Wang,Bojun Jia,Xuefei Guo,Guanghui Yang,Peng Xu,Paul Greengard,Rui Zhou,Yigong Shi

Cell proliferation 54:e13018 PubMed33945189

2021

PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to valvular calcification in rats with CKD.

Applications

Unspecified application

Species

Unspecified reactive species

Liting Wang,Rining Tang,Yuxia Zhang,Sijie Chen,Yu Guo,Xiaochen Wang,Zixiao Liu,Hong Liu,Xiaoliang Zhang,Bi-Cheng Liu

Neuroscience 463:108-115 PubMed33836245

2021

MicroRNA-4422-5p as a Negative Regulator of Amyloidogenic Secretases: A Potential Biomarker for Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Seyedeh Nazanin Hajjari,Saeed Sadigh-Eteghad,Dariush Shanehbandi,Shahram Teimourian,Ali Shahbazi,Mehdi Mehdizadeh
View all publications
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Product promise

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