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AB111947

Anti-GST antibody [EPR4236]

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(30 Publications)

Anti-GST antibody [EPR4236] (ab111947) is a rabbit monoclonal antibody detecting GST in Western Blot, IP, ICC/IF.

- Biophysical QC for unrivalled batch-batch consistency
- Over 20 publications

View Alternative Names

Glutathione S-transferase class-mu 26 kDa isozyme, GST 26, Sj26 antigen, SjGST

16 Images
Immunocytochemistry/ Immunofluorescence - Anti-GST antibody [EPR4236] (AB111947)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GST antibody [EPR4236] (AB111947)

Immunofluorescence staining of 293T cells transfected with GST, with ab111947 at a working dilution of 1/100 and counter-stained with DAPI. Tubulin was also stained with mouse anti-tubulin at a dilution of 1/1000 (ab7291) and Alexa Fluor® 594 goat anti-mouse at a dilution of 1/500 (ab150120). The secondary antibody was Alexa Fluor® 488 goat anti rabbit (ab150077), used at a dilution of 1/500. The cells were fixed in 4% PFA and permeabilized using 0.1% Triton X-100. The negative controls are shown in the bottom hand panels - for the first negative control, anti-GST antibody (ab111947) was used at a dilution of 1/100 followed by an Alexa Fluor® 594 goat anti-mouse antibody (ab150120) at a dilution of 1/1000 and for the second negative control, mouse anti-tubulin (ab7291) and anti-rabbit secondary antibody (ab150077) were used.

Immunoprecipitation - Anti-GST antibody [EPR4236] (AB111947)
  • IP

Supplier Data

Immunoprecipitation - Anti-GST antibody [EPR4236] (AB111947)

(Cross IP) GST immunoprecipitation from transfected 293T whole cell lysate using ab111947. 1 mg of cell lysate was incubated with capture antibody (ab111947) at 1/20 dilution.

Lane 1 : Primary : ab180123, 1/1000 dilution
Sample : 293T transfected with GST tagged protein vector cell lysate 10 ug
Lane 2 : Primary : ab180123, 1/1000 dilution
Sample : 293T transfected with GST tagged protein vector cell lysate
Secondary : ab131366, Veriblot, 1/10000 dilution
Lane 3 : Primary : ab172730, Rabbit monoclonal IgG
Sample : 293T transfected with GST tagged protein vector cell lysate

All lanes : Secondary : ab131366, Veriblot, 1/10000 dilution
Blocking and diluting buffer : 5% NFDM/TBST

All lanes:

Immunoprecipitation - Anti-GST antibody [EPR4236] (ab111947)

Predicted band size: 24 kDa,25 kDa

Observed band size: 28 kDa

false

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Lab

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Lane 1:

GST-tagged human CLIP3/CLIPR-59 recombinant full-length protein at 10 ng

Lane 2:

GST-tagged human CLIP4 recombinant full-length protein at 10 ng

Lane 3:

GST-tagged human CLIP2 recombinant full-length protein at 10 ng

Lane 4:

DDDDK-tagged human CLIP1/CLIP170 HEK293T cell transient overexpression lysate at 10 ng

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Observed band size: 86 kDa

false

Exposure time: 10s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

All lanes:

Western blot - Anti-RNF5/NG2 antibody [EPR27133-30] (<a href='/en-us/products/primary-antibodies/rnf5-ng2-antibody-epr27133-30-ab308066'>ab308066</a>) at 1/1000 dilution

Lane 1:

Human RNF5 recombinant protein

Lane 2:

Human RNF185 recombinant protein

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Observed band size: 45 kDa

false

Exposure time: 180s

Immunoprecipitation - Anti-GST antibody [EPR4236] (AB111947)
  • IP

Supplier Data

Immunoprecipitation - Anti-GST antibody [EPR4236] (AB111947)

GST immunoprecipitation from transfected 293T whole cell lysate using ab111947. 1 mg of cell lysate was incubated with capture antibody (ab111947) at 1/20 dilution.

Blocking and diluting buffer : 5% NFDM/TBST

All lanes:

Immunoprecipitation - Anti-GST antibody [EPR4236] (ab111947) at 1/1000 dilution

Lane 1:

Input - 293T transfected with GST tagged protein vector cell lysate at 10 µg

Lane 2:

(+) 293T transfected with GST tagged protein vector cell lysate

Lane 3:

(-) 293T transfected with GST tagged protein vector cell lysate

Secondary

All lanes:

Immunoprecipitation - VeriBlot for IP Detection Reagent (HRP) (<a href='/en-us/products/reagents/veriblot-for-ip-detection-reagent-hrp-ab131366'>ab131366</a>) at 1/10000 dilution

Predicted band size: 25 kDa

Observed band size: 41 kDa

false

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Unknown

Western blot - Anti-GST antibody [EPR4236] (AB111947)

All lanes:

Western blot - Anti-GST antibody [EPR4236] (ab111947) at 1/1000 dilution

All lanes:

GST recombinant protein at 0.01 µg

Predicted band size: 25 kDa

false

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Unknown

Western blot - Anti-GST antibody [EPR4236] (AB111947)

All lanes:

Western blot - Anti-GST antibody [EPR4236] (ab111947) at 1/1000 dilution

Lane 1:

Alpha-actinin-4-GST fusion protein at 0.01 µg

Lane 2:

AKT1/PKBa-GST fusion protein at 0.01 µg

Lane 3:

CDK7-GST fusion protein at 0.01 µg

Predicted band size: 25 kDa

false

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

This antibody does not cross-react with recombinant human MAGEA1, MAGEA3, MAGEA8, MAGEA6, MAGEA12 or MAGEA2 by western blot.

In Western blot, Anti-6X His tag® antibody [EPR20547] - ChIP Grade (ab213204) staining at 1/5000 dilution.

All lanes:

Western blot - Anti-MAGEA4 antibody [EPR26098-164] (<a href='/en-us/products/primary-antibodies/magea4-antibody-epr26098-164-ab323802'>ab323802</a>) at 1/1000 dilution

Lane 1:

His-tagged human MAGEA4 recombinant protein at 10 ng

Lane 2:

His-tagged human MAGEA1 recombinant protein at 10 ng

Lane 3:

His-tagged human MAGEA3 recombinant protein at 10 ng

Lane 4:

His-tagged human MAGEA8 recombinant protein at 10 ng

Lane 5:

His-tagged human MAGEA6 recombinant protein at 10 ng

Lane 6:

His-tagged human MAGEA12 recombinant protein at 10 ng

Lane 7:

His-tagged human MAGEA2 recombinant protein at 10 ng

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 50 kDa,48 kDa,49 kDa,75 kDa

false

Exposure time: 37s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

In Western blot, Anti-GAPDH antibody [EPR16891] - Loading Control (ab181602) staining at 1/200000 dilution.

In Western blot, Anti-GST antibody [EPR4236] (ab111947) staining at 1/1000 dilution.

All lanes:

Western blot - Anti-AGO1 + AGO2 + AGO3 + AGO4 antibody [RM1196] (<a href='/en-us/products/primary-antibodies/ago1-ago2-ago3-ago4-antibody-rm1196-ab323834'>ab323834</a>) at 1/1000 dilution

Lane 1:

293T (human embryonic kidney epithelial cell) transfected with an empty vector (vector control) containing a myc-His-tag® whole cell lysate at 10 µg

Lane 2:

293T transfected with AGO1 expression vector containing a myc-His-tag®, whole cell lysate at 10 µg

Lane 3:

293T transfected with AGO2 expression vector containing a myc-His-tag®, whole cell lysate at 10 µg

Lane 4:

293T transfected with AGO3 expression vector containing a myc-His-tag®, whole cell lysate at 10 µg

Lane 5:

293T transfected with AGO4 expression vector containing a myc-His-tag®, whole cell lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Observed band size: 125 kDa,36 kDa

false

Exposure time: 6s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Lab

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

ab111947 was used as a GST tag loading control.

All lanes:

Western blot - Anti-SAR1B + SAR1A antibody [EPR10105(B)] (<a href='/en-us/products/primary-antibodies/sar1b-sar1a-antibody-epr10105b-ab155278'>ab155278</a>) at 1/1000 dilution

Lane 1:

Human SAR1B recombinant full-length protein with a GST tag at the N-terminus at 10 ng

Lane 2:

Human SAR1A recombinant full-length protein with a GST tag at the N-terminus at 10 ng

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Observed band size: 48 kDa

false

Exposure time: 3s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Lab

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Western blot : Anti-FOXA1 + FOXA2 + FOXA3 antibody [1B1] ab55178 staining at 1/500 dilution, shown in green; Rabbit anti GST (ab111947) loading control staining at 1/200 dilution, shown in magenta. To generate this image, samples were run on an SDS-PAGE gel then transferred onto a nitrocellulose membrane. Membranes were blocked in 3pc Milk in TBS-0.1 % Tween® 20 (TBS-T) before incubation with primary antibodies overnight at 4°C. Blots were washed four times in TBS-T, incubated with secondary antibodies for 1 h at room temperature, washed again four times then imaged. Secondary antibodies used were Goat anti-Mouse 800CW & Goat anti-Rabbit 680RD at 1/20,000 dilution.

All lanes:

Western blot - Anti-FOXA1 + FOXA2 + FOXA3 antibody [1B1] (<a href='/en-us/products/primary-antibodies/foxa1-antibody-1b1-ab55178'>ab55178</a>) at 1/500 dilution

Lane 1:

FOXA1 Recombinant Protein at 0.1 µg

Lane 2:

FOXA2 Recombinant Protein at 0.1 µg

Lane 3:

FOXA3 Recombinant Protein at 0.1 µg

Secondary

All lanes:

Goat anti-Mouse 800CW & Goat anti-Rabbit 680RD at 1/20000 dilution

Predicted band size: 52 kDa,50 kDa,37 kDa

Observed band size: 78 kDa,76 kDa,63 kDa

false

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Lab

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Blocking and diluting buffer and concentration : 5% NFDM /TBST.

Exposure time :
Lane 1 & 2 : 3 seconds
Lane 3 & 4 : 40 seconds

Lanes 1 - 2:

Western blot - Anti-MAT1A + MAT2A antibody [EPR7938] (<a href='/en-us/products/primary-antibodies/mat1a-mat2a-antibody-epr7938-ab129176'>ab129176</a>) at 1/1000 dilution

Lanes 3 - 4:

Western blot - Anti-GST antibody [EPR4236] (ab111947)

Lanes 1 and 3:

GST-tagged full length MAT1A (Human) recombinant protein at 10 ng

Lanes 2 and 4:

GST-tagged full length MAT2A (Human) recombinant protein at 10 ng

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/20000 dilution

Observed band size: 80 kDa

false

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

This antibody does not cross-react with human PKC alpha, PKC beta 1, PKC beta 2, PKC gamma, PKC delta, PKC eta, PKC theta, PKC mu.

In Western blot, Anti-6X His tag® antibody [EPR20547] - ChIP Grade (ab213204) staining at 1/5000 dilution.

All lanes:

Western blot - Anti-PKC epsilon antibody [EPR28194-50] (<a href='/en-us/products/primary-antibodies/pkc-epsilon-antibody-epr28194-50-ab317498'>ab317498</a>) at 1/1000 dilution

Lane 1:

His-tagged Human PKC epsilon fragment at 10 ng

Lane 2:

GST-tagged full-length Human PKC alpha recombinant protein at 10 ng

Lane 3:

GST-tagged full-length Human PKC beta 1 recombinant protein at 10 ng

Lane 4:

GST-tagged full-length Human PKC beta 2 recombinant protein at 10 ng

Lane 5:

GST-tagged full-length Human PKC gamma recombinant protein at 10 ng

Lane 6:

GST-tagged full-length Human PKC delta recombinant protein at 10 ng

Lane 7:

GST-tagged full-length Human PKC eta recombinant protein at 10 ng

Lane 8:

GST-tagged full-length Human PKC theta recombinant protein at 10 ng

Lane 9:

GST-tagged full-length Human PKC mu recombinant protein at 10 ng

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Observed band size: 26 kDa,85 kDa

false

Exposure time: 180s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

This antibody does not cross-react with human ACSL1 and ACSL5.

In Western blot, Anti-6X His tag® antibody [EPR20547] - ChIP Grade (ab213204) staining at 1/5000 dilution.

In Western blot, Anti-GST antibody [EPR4236] (ab111947) staining at 1/1000 dilution.

All lanes:

Western blot - Anti-ACSL6/ACS2 antibody [EPR29174-76] (<a href='/en-us/products/primary-antibodies/acsl6-acs2-antibody-epr29174-76-ab317703'>ab317703</a>) at 1/1000 dilution

Lane 1:

His-tagged human ACSL6/ACS2 fragment at 10 ng

Lane 2:

GST-tagged human ACSL5 fragment at 10 ng

Lane 3:

His-tagged human ACSL1 fragment at 10 ng

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Observed band size: 15 kDa,37 kDa

false

Exposure time: 180s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

This antibody weakly cross-reacts with Leu-enkephalin.

In Western blot, Anti-Histone H3 antibody [EPR16987] - Nuclear Marker and ChIP Grade (ab176842) staining at 1/100000 dilution.

In Western blot, Anti-6X His tag® antibody [EPR20547] - ChIP Grade (ab213204) staining at 1/5000 dilution.

In Western blot, Anti-GST antibody [EPR4236] (ab111947) staining at 1/1000 dilution.

All lanes:

Western blot - Anti-Met-enkephalin antibody [EPR29582-8] (<a href='/en-us/products/primary-antibodies/met-enkephalin-antibody-epr29582-8-ab325400'>ab325400</a>) at 1/1000 dilution

Lane 1:

293T (human embryonic kidney epithelial cell) transfected with an empty vector (vector control) containing both a Myc-His tag and a GST tag, whole cell lysate at 1 µg

Lane 2:

293T transfected with Met-enkephalin expression vector containing both a Myc-His tag and a GST tag, whole cell lysate at 1 µg

Lane 3:

293T transfected with Leu-enkephalin expression vector containing both a Myc-His tag and a GST tag, whole cell lysate at 1 µg

Lane 4:

293T transfected with a-Endorphin expression vector containing both a Myc-His tag and a GST tag, whole cell lysate at 1 µg

Lane 5:

293T transfected with Dynorphin A expression vector containing both a Myc-His tag and a GST tag, whole cell lysate at 1 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab97051'>ab97051</a>) at 1/100000 dilution

Observed band size: 30 kDa,15 kDa

false

Exposure time: 3s

Western blot - Anti-GST antibody [EPR4236] (AB111947)
  • WB

Supplier Data

Western blot - Anti-GST antibody [EPR4236] (AB111947)

Blocking and diluting buffer and concentration : 5% NFDM /TBST. Exposure time : Lane 1 : 1 second. Lane 2 : 20 seconds. AMBN will migrate to higher MW size (PMID : 23782691), the MW is consistent with literature (PMID : 26070558).

Lane 1:

Western blot - Anti-AMBN antibody [EPR8317] (<a href='/en-us/products/primary-antibodies/ambn-antibody-epr8317-ab155950'>ab155950</a>) at 1/1000 dilution

Lane 2:

Western blot - Anti-GST antibody [EPR4236] (ab111947) at 1/1000 dilution

All lanes:

Recombinant AMBN protein

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Predicted band size: 48 kDa

Observed band size: 100 kDa

false

  • Carrier free

    Anti-GST antibody [EPR4236] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4236

Isotype

IgG

Carrier free

No

Applications

ICC/IF, WB, IP

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/20", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "<p></p>" } } }
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Product details

What is this antibody validated in?
Anti-GST antibody [EPR4236] (ab111947) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF). What is the molecular weight of GST?
Anti-GST [EPR4236] (ab111947) specifically detects a band for GST (UniProt: Q676U5) at a molecular weight of 26kDa.

Trusted by the scientific community
Anti-GST [EPR4236] (ab111947) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.

Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Other related products
We have a range of other formats of antibody clone [EPR4236] also available for your convenience: ab111947, Carrier free - ab235384

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.
Biological function summary

GST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.

Pathways

GST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.

GSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
See full target information Glutathione S-transferase class-mu 26 kDa isozyme
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Publications (30)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadt9645 PubMed40845099

2025

Microbiota metabolite taurodeoxycholic acid maintains intestinal tissue residency of innate lymphoid cells via engagement with P2Y10 receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Yuwei Xu,Zhen Xiong,Peikang Zhang,Runyuan Wu,Cunzhen Li,Hui Guo,Ying Du,Xiaoxiao Zhu,Dongdong Fan,Hongzhe Fan,Yong Tian,Yun Chen,Zusen Fan

Research (Washington, D.C.) 8:0703 PubMed40416363

2025

Targeting the Exonic Circular RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Qilan Li,Yang Cheng,Chunhui Yang,Minxiu Tian,Xiaojing Wang,Dan Li,Xinyue Li,Jiaying Qu,Shunchen Zhou,Liduan Zheng,Qiangsong Tong

Communications biology 8:489 PubMed40133702

2025

PTOV1 interacts with ZNF449 to promote colorectal cancer development.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyong Wang,Xinwei Qiao,Kaming Xue,Qianzhi Chen,Anshu Li

Cellular & molecular biology letters 30:28 PubMed40045194

2025

tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jialyu Huang,Jiawei Wang,Shuang Wang,Xiangpeng Xiong,Ruiyin Jiang,Chaoyi Xiong,Lu Wang,Lingling Huang,Yan Zhao,Zheng Fang,Xiaoyan Ai,Jiaying Lin

Nature communications 15:10088 PubMed39572526

2024

Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yalei Wen,Hui Wang,Xiao Yang,Yingjie Zhu,Mei Li,Xiuqing Ma,Lei Huang,Rui Wan,Caishi Zhang,Shengrong Li,Hongling Jia,Qin Guo,Xiaoyun Lu,Zhengqiu Li,Xiangchun Shen,Qiushi Zhang,Lu Si,Chengqian Yin,Tongzheng Liu

Nature communications 15:8039 PubMed39271725

2024

Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Wu,Qiongdan Zhang,Yuhan Lin,Wai Hei Lam,Yuanliang Zhai

Autophagy 20:329-348 PubMed37776538

2023

CENPN suppresses autophagy and increases paclitaxel resistance in nasopharyngeal carcinoma cells by inhibiting the CREB-VAMP8 signaling axis.

Applications

Unspecified application

Species

Unspecified reactive species

Bin-Ru Wang,Ji-Bo Han,Yang Jiang,Shan Xu,Rui Yang,Yong-Gang Kong,Ze-Zhang Tao,Qing-Quan Hua,You Zou,Shi-Ming Chen

Gland surgery 12:963-973 PubMed37727335

2023

ERα promotes transcription by binding with the ERE and enhances SUMO1-mediated protein SUMOylation in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Quhui Wang,Nannan Zhang,Xiaobing Yang,Shichun Feng,Feiran Wang,Wei Zhang,Zhixian He

Science advances 9:eade5584 PubMed36753544

2023

Metabolite asymmetric dimethylarginine (ADMA) functions as a destabilization enhancer of SOX9 mediated by DDAH1 in osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Yizheng Wu,Shuying Shen,Jiaxin Chen,Weiyu Ni,Qinxin Wang,Hongyi Zhou,Junxin Chen,Haitao Zhang,Zixuan Mei,Xuewu Sun,Panyang Shen,Zhiwei Jie,Wenbin Xu,Zhenghua Hong,Yan Ma,Kefan Wang,Shuanglin Wan,Hongfei Wu,Ziang Xie,An Qin,Shunwu Fan

Frontiers in cell and developmental biology 10:902403 PubMed36092721

2022

PLK1-mediated phosphorylation of PPIL2 regulates HR CtIP.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyu Qiu,Shuailin Hao,Shikai Song,Ruiling Zhang,Tingyu Yan,Zhifang Lu,Hailong Wang,Zongchao Jia,Jimin Zheng
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