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AB36415

Anti-GST antibody [S-tag-05]

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(6 Publications)

Mouse Monoclonal GST antibody. Suitable for IP, WB and reacts with Tag samples. Cited in 6 publications.

View Alternative Names

Glutathione S-transferase class-mu 26 kDa isozyme, GST 26, Sj26 antigen, SjGST

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

S-tag-05

Isotype

IgG2b

Carrier free

No

Applications

WB, IP

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Tag": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Product details

ab36415 is a mouse monoclonal antibody with high affinity to the glutathione-S-transferase (GST) from Schistosoma japonicum.This purified antibody will detect the expressed GST protein or a GST-fusion protein, and can be utilized for immuno-purification of GST-fusion proteins.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.
Biological function summary

GST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.

Pathways

GST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.

GSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
See full target information Glutathione S-transferase class-mu 26 kDa isozyme
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:5535 PubMed38951545

2024

Amyloid formation and depolymerization of tumor suppressor p16 are regulated by a thiol-dependent redox mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah G Heath,Shelby G Gray,Emilie M Hamzah,Karina M O'Connor,Stephanie M Bozonet,Alex D Botha,Pierre de Cordovez,Nicholas J Magon,Jennifer D Naughton,Dylan L W Goldsmith,Abigail J Schwartfeger,Margaret Sunde,Alexander K Buell,Vanessa K Morris,Christoph Göbl

Cancer science 113:2753-2762 PubMed35722967

2022

Hippo pathway monomerizes STAT3 to regulate prostate cancer growth.

Applications

Unspecified application

Species

Unspecified reactive species

Qingfeng Tang,Jing Fang,Weiqi Lai,Yu Hu,Chengwan Liu,Xiaobo Hu,Caiyong Song,Tianmu Cheng,Rui Liu,Xiaoke Huang

Cell death and differentiation 29:206-217 PubMed34465890

2021

Mechanosensitive turnover of phosphoribosyl pyrophosphate synthetases regulates nucleotide metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyi Li,Jichun Shao,Zhijun Zeng,Yumin He,Can Tang,Su Hwan Park,Jong-Ho Lee,Rui Liu

Frontiers in immunology 10:3003 PubMed32010127

2020

Thoroughly Remold the Localization and Signaling Pathway of TLR22.

Applications

Unspecified application

Species

Unspecified reactive species

Jianfei Ji,Zhiwei Liao,Youliang Rao,Wenqian Li,Chunrong Yang,Gailing Yuan,Hao Feng,Zhen Xu,Jianzhong Shao,Jianguo Su

NPJ precision oncology 3:27 PubMed31701018

2019

Propranolol exhibits activity against hemangiomas independent of beta blockade.

Applications

Unspecified application

Species

Unspecified reactive species

Maiko Sasaki,Paula E North,Justin Elsey,Jeffrey Bubley,Shikha Rao,Yoonhee Jung,Shengnan Wu,Ming-Hui Zou,Brian P Pollack,Jayanth Kumar,Hartej Singh,Jack L Arbiser

Molecular biotechnology 60:887-900 PubMed30259259

2018

Systematic Comparison of Strategies to Achieve Soluble Expression of Plasmodium falciparum Recombinant Proteins in E. coli.

Applications

Unspecified application

Species

Unspecified reactive species

Liliana Morales,Paula Hernández,Jacqueline Chaparro-Olaya
View all publications
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Product promise

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