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AB211449

Anti-GSTA2 antibody

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(1 Publication)

Rabbit Polyclonal GSTA2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GSTA2 aa 1-200.

View Alternative Names

GST2, GSTA2, Glutathione S-transferase A2, GST HA subunit 2, GST class-alpha member 2, GST-gamma, GSTA2-2, GTH2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-GSTA2 antibody (AB211449)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GSTA2 antibody (AB211449)

Immunofluorescence analysis of methanol fixed, HepG2 cells labeling GSTA2 with ab211449 at a 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB211449)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA2 antibody (AB211449)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney tissue labeling GSTA2 with ab211449 at 5μg/mL.

Western blot - Anti-GSTA2 antibody (AB211449)
  • WB

Supplier Data

Western blot - Anti-GSTA2 antibody (AB211449)

12% SDS PAGE.

All lanes:

Western blot - Anti-GSTA2 antibody (ab211449) at 1/3000 dilution

All lanes:

HepG2 whole cell lysate at 30 µg

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GSTA2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P09210

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 89% Tris glycine, 10% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Glutathione S-transferase alpha 2 (GSTA2) plays an important mechanical role in detoxification processes. GSTA2 belongs to the family of glutathione S-transferases and has a mass of approximately 25 kDa. This enzyme is known for catalyzing the conjugation of the reduced form of glutathione to various substrates aiding in their solubility and subsequent excretion from the body. GSTA2 is mainly expressed in the liver but it can also be found in other tissues such as the kidney and intestine exposed to oxidative stress and toxicants.
Biological function summary

GSTA2 contributes significantly to protecting cells from oxidative damage and chemical stress. It does not form part of a larger protein complex but acts as an important defense line in detoxifying endogenous and exogenous compounds. The presence of GSTA2 ensures the maintenance of cellular redox balance by eliminating harmful electrophiles and peroxides that could cause cellular damage.

Pathways

GSTA2 is an essential component of the drug metabolism and glutathione conjugation pathways. In these pathways it cooperates with other glutathione S-transferases to facilitate the transformation of toxic substances into less harmful compounds. GSTA2 shares functional similarities with proteins like GSTP1 which also participate in the glutathione transferase activity under stressful environmental conditions. These pathways ensure cellular resilience against chemical insults maintaining homeostasis and cellular function.

GSTA2 has notable connections to cancer and liver disease. Research shows changes in GSTA2 expression levels in various cancers where altered detoxification processes contribute to tumor development and progression. In liver diseases varying GSTA2 activities influence the liver’s ability to manage oxidative stress and perform detoxification. GSTA2 shows interaction with proteins such as CYP enzymes which are also involved in drug and xenobiotic metabolism influencing disease outcomes and treatment responses.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds.
See full target information GSTA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Microorganisms 12: PubMed39065185

2024

Exosomal Small RNA Sequencing Profiles in Plasma from Subjects with Latent Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaogang Cui,Hangting Meng,Miao Li,Xia Chen,Dan Yuan,Changxin Wu
View all publications
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Product promise

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