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AB203311

Anti-GSTA3 antibody

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(1 Publication)

Rabbit Polyclonal GSTA3 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GSTA3 aa 150 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Glutathione S-transferase A3, GST class-alpha member 3, Glutathione S-transferase A3-3, GSTA3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA3 antibody (AB203311)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA3 antibody (AB203311)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse brain tissue labeling GSTA3 with ab203311 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GSTA3 aa 150 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q16772

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe the recommended dilution is 1/50 – 1/200.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTA3 also known as Glutathione S-transferase alpha 3 is an enzyme involved in the detoxification processes. It exhibits a molecular mass of approximately 25 kDa. GSTA3 functions by catalyzing the conjugation of reduced glutathione to hydrophobic and electrophilic compounds facilitating their solubility and excretion. It is expressed mainly in the liver albeit at various levels in other tissues including kidney and pancreas. This enzyme plays an important role in preventing cellular damage from reactive metabolites and toxins.
Biological function summary

GSTA3 acts in the neutralization of oxidative stress by reducing lipid hydroperoxides to their alcohol forms and supporting the intracellular antioxidant defense. While GSTA3 functions as a monomer it can form homodimers or heterodimers with other isoenzymes enhancing its functional diversity. This capability allows GSTA3 to partake in metabolizing a wide array of endogenous and xenobiotic substrates maintaining cellular health.

Pathways

GSTA3 plays a part in the glutathione metabolism and xenobiotic clearance. It plays an essential role in the detoxification pathway acting in conjunction with other glutathione S-transferases such as GSTM1 and GSTP1. Together these proteins form a network that facilitates detoxification and protects against oxidative damage in tissues. The capacity of GSTA3 to mitigate harmful chemical interactions places it in central biological pathways that uphold cellular integrity.

Alterations or deficiencies in GSTA3 expression or function associate with an increased risk of liver diseases and certain cancers. Due to its role in detoxifying carcinogens compromised GSTA3 activity can lead to carcinogenesis particularly in hepatic tissues. Additionally research reveals interactions with proteins like GSTM1 in the context of cancer where combined effects further influence susceptibility to disease. Understanding the mechanistic role of GSTA3 in these conditions may provide insights into therapeutic interventions and biomarker development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Has substantial activity toward aflatoxin B1-8,9-epoxide (By similarity).
See full target information GSTA3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell host & microbe 30:1382-1400.e8 PubMed36099922

2022

A dissemination-prone morphotype enhances extrapulmonary organ entry by Cryptococcus neoformans.

Applications

Unspecified application

Species

Unspecified reactive species

Steven T Denham,Brianna Brammer,Krystal Y Chung,Morgan A Wambaugh,Joseph M Bednarek,Li Guo,Christian T Moreau,Jessica C S Brown
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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