AB134919

Anti-GSTA4 antibody [EPR8404(B)]

Name: Anti-GSTA4 antibody [EPR8404(B)] (ab134919) | Abcam
Brand: Abcam Limited
SKU: AB134919
Price: 330 USD
Availability: InStock
Rating: 4 (1 reviews)

RabMAb
Recombinant
What is this?

(1 Review)

(4 Publications)

Rabbit Recombinant Monoclonal GSTA4 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

Glutathione S-transferase A4, GST class-alpha member 4, Glutathione S-transferase A4-4, GSTA4

1 Images

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Western blot - Anti-GSTA4 antibody [EPR8404(B)] (AB134919)

All lanes:

Western blot - Anti-GSTA4 antibody [EPR8404(B)] (ab134919) at 1/1000 dilution

Lane 1:

Human fetal brain lysate at 10 µg

Lane 2:

Human fetal liver lysate at 10 µg

Lane 3:

293T cell lysate at 10 µg

Lane 4:

HepG2 cell lysate at 10 µg

Lane 5:

JAR cell lysate at 10 µg

Secondary

All lanes:

Goat-anti-rabbit HRP at 1/2000 dilution

Predicted band size: 26 kDa

true

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8404(B)

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Species reactivity
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTA4 also known as Glutathione S-transferase alpha-4 is an enzyme that plays a critical role in detoxification processes. This protein weighs approximately 25 kDa and exhibits strong expression in tissues such as the liver kidney and brain. GSTA4 belongs to the glutathione S-transferase superfamily specifically the alpha class which is involved in the conjugation of the reduced form of glutathione (GSH) to a wide range of hydrophobic electrophiles.

Biological function summary

GSTA4 helps in the metabolism of lipid peroxidation products by catalyzing their conjugation with glutathione. This process is essential for reducing oxidative stress caused by cellular metabolism. GSTA4 does not normally function as part of a larger complex but instead works independently to carry out this detoxification role. The ability of GSTA4 to target lipid peroxidation products is significant for cellular protection mechanisms.

Pathways

GSTA4 actively participates in the detoxification pathway where it neutralizes harmful compounds like 4-hydroxynonenal (4-HNE) a byproduct of lipid peroxidation. GSTA4 is also involved in the glutathione metabolism pathway playing an important role alongside other GST isoforms in managing oxidative stress within cells. Proteins related through these pathways include other members of the glutathione S-transferase family which share similar functional roles in detoxification processes.

GSTA4 impacts the development of conditions related to oxidative stress such as Alzheimer's disease and cancer. Through its detoxifying activity GSTA4 helps mitigate oxidative damage that may contribute to the progression of these diseases. Research indicates the dysregulation of GSTA4 expression links to both Alzheimer's disease and cancer along with its interactions with other GST family proteins highlighting its importance in disease pathology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).

See full target information Glutathione S-transferase A4

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed39823539

2025

N-glycosylation in the SERPIN domain of the C1-esterase inhibitor in hereditary angioedema.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Ren,John Bao,Shuangxia Zhao,Nicola Pozzi,H James Wedner,John P Atkinson

Cells 12: PubMed36899865

2023

Differential Effects of Nonsteroidal Anti-Inflammatory Drugs in an In Vitro Model of Human Leaky Gut.

Applications

Unspecified application

Species

Unspecified reactive species

Michele d'Angelo,Laura Brandolini,Mariano Catanesi,Vanessa Castelli,Cristina Giorgio,Margherita Alfonsetti,Mara Tomassetti,Mara Zippoli,Elisabetta Benedetti,Maria Candida Cesta,Sandro Colagioia,Pasquale Cocchiaro,Annamaria Cimini,Marcello Allegretti

Molecular metabolism 69:101686 PubMed36746333

2023

Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Hélène Dehondt,Arianna Marino,Laura Butruille,Denis A Mogilenko,Arielle C Nzoussi Loubota,Oscar Chávez-Talavera,Emilie Dorchies,Emmanuelle Vallez,Joel Haas,Bruno Derudas,Antonino Bongiovanni,Meryem Tardivel,Folkert Kuipers,Philippe Lefebvre,Sophie Lestavel,Anne Tailleux,David Dombrowicz,Sandrine Caron,Bart Staels

Molecular oncology 14:329-346 PubMed31782885

2019

UHRF1 downmodulation enhances antitumor effects of histone deacetylase inhibitors in retinoblastoma by augmenting oxidative stress-mediated apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jong Kyong Kim,Guangyan Kan,Yu Mao,Zhixuan Wu,Xionghong Tan,Heng He,Chunsik Lee

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GSTA4 antibody [EPR8404(B)]

Western blot - Anti-GSTA4 antibody [EPR8404(B)] (AB134919)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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