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AB232871

Anti-GSTA5 antibody

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(1 Publication)

Rabbit Polyclonal GSTA5 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Rat Gsta5.

View Alternative Names

Glutathione S-transferase A5, GST class-alpha member 5, Glutathione S-transferase A5-5, GSTA5

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA5 antibody (AB232871)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA5 antibody (AB232871)

Formalin-fixed, paraffin-embedded rat liver tissue stained for GSTA5 using ab232810 at 20 μg/ml in immunohistochemical analysis.

Secondary used : HRP-Linked Goat anti-Rabbit IgG polyclonal at 2 μg/ml. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA5 antibody (AB232871)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTA5 antibody (AB232871)

Formalin-fixed, paraffin-embedded rat kidney tissue stained for GSTA5 using ab232810 at 20 μg/ml in immunohistochemical analysis.

Secondary used : HRP-Linked Goat anti-Rabbit IgG polyclonal at 2 μg/ml. DAB staining.

Western blot - Anti-GSTA5 antibody (AB232871)
  • WB

Supplier Data

Western blot - Anti-GSTA5 antibody (AB232871)

All lanes:

Western blot - Anti-GSTA5 antibody (ab232871) at 2 µg/mL

All lanes:

Recombinant rat GSTA5

Predicted band size: 25 kDa,26 kDa

false

Western blot - Anti-GSTA5 antibody (AB232871)
  • WB

Supplier Data

Western blot - Anti-GSTA5 antibody (AB232871)

All lanes:

Western blot - Anti-GSTA5 antibody (ab232871) at 2 µg/mL

All lanes:

Human liver tissue lysate

Secondary

All lanes:

HRP-Linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 25 kDa

false

Western blot - Anti-GSTA5 antibody (AB232871)
  • WB

Supplier Data

Western blot - Anti-GSTA5 antibody (AB232871)

All lanes:

Western blot - Anti-GSTA5 antibody (ab232871) at 2 µg/mL

All lanes:

Rat liver tissue lysate

Secondary

All lanes:

HRP-Linked Goat anti-Rabbit IgG polyclonal at 0.2 µg/mL

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Rat Gsta5.

P46418

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTA5 also known as Glutathione S-transferase A5 belongs to the glutathione S-transferase (GST) family which is a group of enzymes involved in detoxification processes. It has a molecular mass of approximately 26 kDa. These enzymes function by catalyzing the conjugation of glutathione to a variety of exogenous and endogenous compounds facilitating their solubility and excretion. GSTA5 is mostly expressed in the liver but researchers have also detected its presence in other tissues such as the kidneys and lungs.
Biological function summary

Enzymes from the GST family like GSTA5 play integral roles in protecting cells from oxidative damage. By facilitating the conjugation of reduced glutathione GSTA5 contributes to neutralizing reactive oxygen species (ROS) that can harm cellular components. While GSTA5 is not part of a larger complex its activity is essential for maintaining a balance between cellular defense mechanisms and toxicant processing particularly in organs with high detoxification demands.

Pathways

GSTA5's activity is central to the drug metabolism and detoxification pathways. It supports phase II biotransformation processes where it interacts with other GST family members such as GSTP1 and GSTM1 which assists in the detoxification of harmful substances. This process ultimately leads to the excretion of toxins and protection against their detrimental effects on cellular function thereby playing a critical part in safeguarding cellular health.

Researchers have linked GSTA5 to conditions involving oxidative stress and toxic exposure such as liver cirrhosis and certain cancers. Altered expression or function of GSTA5 can result in compromised detoxification processes which increases susceptibility to these conditions. In liver-related disorders GSTA5 often interacts with enzymes like cytochrome P450s which are pivotal in drug metabolism. Understanding the role of GSTA5 in these contexts aids in the development of potential therapeutic strategies targeting detoxification pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information GSTA5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular biosciences 8:764900 PubMed34966781

2021

ELK1 Enhances Pancreatic Cancer Progression Via LGMN and Correlates with Poor Prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Yan,Chenming Ni,Yingying Lin,Xu Sun,Zhenhua Shen,Minjie Zhang,Shuwen Han,Jiemin Shi,Jing Mao,Zhe Yang,Weilin Wang
View all publications
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