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AB244483

Anti-GSTM1 antibody

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(1 Publication)

Rabbit Polyclonal GSTM1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GSTM1 aa 1-50.

View Alternative Names

GST1, GSTM1, Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)

Immunohistochemical analysis of human kidney tissue labelling GSTM1 with ab244483 shows strong granular cytoplasmatic positivity in cells in tubules.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)

Immunohistochemical analysis of human liver tissue labelling GSTM1 with ab244483 shows strong granular cytoplasmatic positivity in hepatocytes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)

Immunohistochemical analysis of human small intestine tissue labelling GSTM1 with ab244483 shows strong granular cytoplasmatic positivity in glandular cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM1 antibody (AB244483)

Immunohistochemical analysis of human prostate tissue labelling GSTM1 with ab244483 shows strong granular cytoplasmatic positivity in glandular cells.

Western blot - Anti-GSTM1 antibody (AB244483)
  • WB

Supplier Data

Western blot - Anti-GSTM1 antibody (AB244483)

All lanes:

Western blot - Anti-GSTM1 antibody (ab244483) at 0.4 µg/mL

Lane 1:

HeLa (human cervix adenocarcinoma epithelial cell) whole cell lysate

Lane 2:

U-2 OS (human bone osteosarcoma epithelial cell line) whole cell lysate

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human GSTM1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P09488

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GSTM1 protein also known as Glutathione S-transferase Mu 1 plays important roles in cellular detoxification processes. It belongs to the glutathione S-transferase family of enzymes which are involved in the conjugation of reduced glutathione to xenobiotic substrates for the purpose of detoxification. GSTM1 has a molecular mass of approximately 26 kDa. This protein expresses mostly in liver and kidney tissues but has presence in other tissues like lung and testis as well.
Biological function summary

GSTM1 acts in metabolism of endogenous and xenobiotic compounds. It does not work alone but rather functions as part of enzyme complexes that alter chemical structure of toxic substances making them safer for cellular systems. GSTM1 helps in protecting cells from damage caused by oxidative stress. The interaction of this protein with glutathione provides a protective mechanism against toxic chemicals such as carcinogens and electrophiles.

Pathways

GSTM1 has significant involvement in metabolic detoxification and the glutathione-mediated pathway. It plays a role in the metabolism of drugs and clearance of harmful compounds in these pathways. It often interacts with other proteins like GSTP1 and GSTT1 within these pathways working together to facilitate cellular defense mechanisms. GSTM1 contributes importantly to maintaining cellular redox homeostasis by its enzymatic activities.

GSTM1 shows a connection to various cancers and cardiovascular diseases. The absence or null genotype of GSTM1 associates with higher risk of developing certain cancers like bladder and lung cancer due to impaired detoxification capacity. In cardiovascular diseases the protein's deficiency can disrupt normal oxidative stress balance. GSTP1 operates alongside GSTM1 in pathological situations with their combined functions influencing disease susceptibility and progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed : 9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed : 21046276).
See full target information GSTM1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta neuropathologica communications 11:84 PubMed37217978

2023

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function.

Applications

Unspecified application

Species

Unspecified reactive species

Luise A Seeker,Nadine Bestard-Cuche,Sarah Jäkel,Nina-Lydia Kazakou,Sunniva M K Bøstrand,Laura J Wagstaff,Justyna Cholewa-Waclaw,Alastair M Kilpatrick,David Van Bruggen,Mukund Kabbe,Fabio Baldivia Pohl,Zahra Moslehi,Neil C Henderson,Catalina A Vallejos,Gioele La Manno,Goncalo Castelo-Branco,Anna Williams
View all publications
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