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AB196503

Anti-GSTM2 antibody

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(4 Publications)

Rabbit Polyclonal GSTM2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GSTM2.

View Alternative Names

GST4, GSTM2, Glutathione S-transferase Mu 2, GST class-mu 2, GSTM2-2

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM2 antibody (AB196503)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM2 antibody (AB196503)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling GSTM2 with ab196503 at 1/200 dilution (200x lens).

Immunocytochemistry/ Immunofluorescence - Anti-GSTM2 antibody (AB196503)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GSTM2 antibody (AB196503)

Immunofluorescent analysis of HeLa cells labeling GSTM2 with ab196503 at 1/50 dilution. Lower image shows DAPI for nuclear staining (Blue).

Western blot - Anti-GSTM2 antibody (AB196503)
  • WB

Supplier Data

Western blot - Anti-GSTM2 antibody (AB196503)

All lanes:

Western blot - Anti-GSTM2 antibody (ab196503) at 1/500 dilution

Lane 1:

Mouse testis extract

Lane 2:

Mouse heart extract

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human GSTM2.

P28161

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Alternative Products

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Complementary Products

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Cell Lines & Lysates

AB265995

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTM2 or Glutathione S-transferase Mu 2 is an enzyme with a mass of approximately 25 kDa. This protein functions mechanically by catalyzing the conjugation of glutathione to various hydrophobic and electrophilic compounds which enhances their solubility and facilitates their excretion. The enzyme is expressed in many tissues with high levels in the liver brain and lungs contributing to detoxification processes within these organs.
Biological function summary

The enzyme GSTM2 plays a critical role in cellular protection against oxidative stress and toxic compounds. It functions as part of a complex detoxification system interacting with reactive intermediates to prevent cellular damage. GSTM2 acts synergistically with other enzymes in the glutathione-dependent pathways to maintain cellular integrity and prevent damage from free radicals and peroxides.

Pathways

GSTM2 is heavily involved in cellular detoxification pathways and the metabolism of xenobiotics. It connects to the glutathione metabolism pathway working alongside proteins such as GSTP1 and GSTA1. These pathways are essential for protecting cells from oxidative damage and managing cellular responses to stress making GSTM2 an important player in maintaining cellular homeostasis.

GSTM2 has implications in cancer and asthma. Altered expression levels and polymorphisms in the GSTM2 gene can associate with increased cancer risk due to the impaired ability to detoxify carcinogens. In asthma changes in GSTM2 expression may contribute to an improper response to oxidative stress and inflammation. Related proteins like GSTP1 also share involvement in these conditions underlining the significance of the glutathione S-transferase family in disease susceptibility.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed : 21046276).
See full target information GSTM2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology :18974 PubMed40772306

2025

Suppressing SMURF1 to preserve GSTM2: An approach to reducing gastric cancer aggressiveness and .

Applications

Unspecified application

Species

Unspecified reactive species

Guoming Ma,Jingwu Li,Yuanting Lu,Weiwei Zuo

Cell & bioscience 13:220 PubMed38037116

2023

GSTM2 alleviates heart failure by inhibiting DNA damage in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Hongfei Xu,Zhen Wang,Yalin Wang,Shaobo Pan,Wenting Zhao,Miao Chen,Xiaofan Chen,Tingting Tao,Liang Ma,Yiming Ni,Weidong Li

FASEB journal : official publication of the Federa 33:13794-13807 PubMed31589826

2019

Biosynthetic metabolomes of cysteinyl-containing immunoresolvents.

Applications

Unspecified application

Species

Unspecified reactive species

Charlotte C Jouvene,Ashley E Shay,Mieke A Soens,Paul C Norris,Jesper Z Haeggström,Charles N Serhan

Journal of experimental & clinical cancer research 38:292 PubMed31287003

2019

Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Christin Richter,Stephan Marquardt,Fanghua Li,Alf Spitschak,Nico Murr,Berdien A H Edelhäuser,George Iliakis,Brigitte M Pützer,Stella Logotheti
View all publications
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Product promise

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