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AB232860

Anti-GSTM2 antibody

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(1 Publication)

Rabbit Polyclonal GSTM2 antibody. Suitable for WB and reacts with Mouse, Pig, Rat, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GSTM2 aa 1 to C-terminus.

View Alternative Names

GST4, GSTM2, Glutathione S-transferase Mu 2, GST class-mu 2, GSTM2-2

2 Images
Western blot - Anti-GSTM2 antibody (AB232860)
  • WB

Supplier Data

Western blot - Anti-GSTM2 antibody (AB232860)

All lanes:

Western blot - Anti-GSTM2 antibody (ab232860) at 2 µg/mL

Lane 1:

Mouse liver lysate

Lane 2:

Pig liver lysate

Lane 3:

Rat brain lysate

Predicted band size: 26 kDa

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Western blot - Anti-GSTM2 antibody (AB232860)
  • WB

Supplier Data

Western blot - Anti-GSTM2 antibody (AB232860)

All lanes:

Western blot - Anti-GSTM2 antibody (ab232860) at 2 µg/mL

All lanes:

Recombinant human GSTM2 protein

Predicted band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human, Pig

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human GSTM2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P28161

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab232860 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTM2 or Glutathione S-transferase Mu 2 is an enzyme with a mass of approximately 25 kDa. This protein functions mechanically by catalyzing the conjugation of glutathione to various hydrophobic and electrophilic compounds which enhances their solubility and facilitates their excretion. The enzyme is expressed in many tissues with high levels in the liver brain and lungs contributing to detoxification processes within these organs.
Biological function summary

The enzyme GSTM2 plays a critical role in cellular protection against oxidative stress and toxic compounds. It functions as part of a complex detoxification system interacting with reactive intermediates to prevent cellular damage. GSTM2 acts synergistically with other enzymes in the glutathione-dependent pathways to maintain cellular integrity and prevent damage from free radicals and peroxides.

Pathways

GSTM2 is heavily involved in cellular detoxification pathways and the metabolism of xenobiotics. It connects to the glutathione metabolism pathway working alongside proteins such as GSTP1 and GSTA1. These pathways are essential for protecting cells from oxidative damage and managing cellular responses to stress making GSTM2 an important player in maintaining cellular homeostasis.

GSTM2 has implications in cancer and asthma. Altered expression levels and polymorphisms in the GSTM2 gene can associate with increased cancer risk due to the impaired ability to detoxify carcinogens. In asthma changes in GSTM2 expression may contribute to an improper response to oxidative stress and inflammation. Related proteins like GSTP1 also share involvement in these conditions underlining the significance of the glutathione S-transferase family in disease susceptibility.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed : 21046276).
See full target information GSTM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 9:e21616 PubMed38027820

2023

Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study.

Applications

Unspecified application

Species

Unspecified reactive species

Lingyan Chen,Jingyang Li,Yilan You,Zhiwen Qian,Jiayu Liu,Ying Jiang,Ying Gu,Jianping Xiao,Yan Zhang
View all publications
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