Anti-GSTM2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GSTM2 or Glutathione S-transferase Mu 2 is an enzyme with a mass of approximately 25 kDa. This protein functions mechanically by catalyzing the conjugation of glutathione to various hydrophobic and electrophilic compounds which enhances their solubility and facilitates their excretion. The enzyme is expressed in many tissues with high levels in the liver brain and lungs contributing to detoxification processes within these organs.

Biological function summary

The enzyme GSTM2 plays a critical role in cellular protection against oxidative stress and toxic compounds. It functions as part of a complex detoxification system interacting with reactive intermediates to prevent cellular damage. GSTM2 acts synergistically with other enzymes in the glutathione-dependent pathways to maintain cellular integrity and prevent damage from free radicals and peroxides.

Pathways

GSTM2 is heavily involved in cellular detoxification pathways and the metabolism of xenobiotics. It connects to the glutathione metabolism pathway working alongside proteins such as GSTP1 and GSTA1. These pathways are essential for protecting cells from oxidative damage and managing cellular responses to stress making GSTM2 an important player in maintaining cellular homeostasis.

Associated diseases and disorders

GSTM2 has implications in cancer and asthma. Altered expression levels and polymorphisms in the GSTM2 gene can associate with increased cancer risk due to the impaired ability to detoxify carcinogens. In asthma changes in GSTM2 expression may contribute to an improper response to oxidative stress and inflammation. Related proteins like GSTP1 also share involvement in these conditions underlining the significance of the glutathione S-transferase family in disease susceptibility.