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AB317141

Anti-GSX2 antibody [HL2135]

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Rabbit Recombinant Monoclonal GSX2 antibody. Suitable for WB, ICC/IF and reacts with Transfected cell lysate, Rat, Recombinant full length protein samples. Immunogen corresponding to Recombinant Fragment Protein within Human GSX2.

View Alternative Names

GSH2, GSX2, GS homeobox 2, Genetic-screened homeobox 2, Homeobox protein GSH-2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-GSX2 antibody [HL2135] (AB317141)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GSX2 antibody [HL2135] (AB317141)

ab317141 detects GSX2 protein at nucleus by immunofluorescent analysis. Sample : DIV9 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green : GSX2 stained by GSX2 antibody ab317141 diluted at 1 : 250. Red : Tau an axon marker stained by Tau antibody [GT287] diluted at 1 : 500.

Immunocytochemistry/ Immunofluorescence - Anti-GSX2 antibody [HL2135] (AB317141)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-GSX2 antibody [HL2135] (AB317141)

Immunofluorescence analysis of Mock and transfected 293T cells fixed in 4% paraformaldehyde at RT for 15 min labelling GSX2 protein using ab317141 at a 1/500 dilution (Green).
DAPI was used for nuclear staining (Blue).

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL2135

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human GSX2.

Q9BZM3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Recombinant full length protein": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Transfected cell lysate": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSH2 also known as glutathione synthetase 2 adds up to gamma-glutamylcysteine to create glutathione a tripeptide important in cellular defense against oxidative stress. It has a molecular mass of approximately 52 kDa. GSH2 shows expression in various tissues with higher levels in the liver and kidneys due to their roles in detoxification processes.
Biological function summary

The role of GSH2 involves maintaining intracellular redox balance and detoxifying harmful substances. GSH2 works closely with glutamate-cysteine ligase in the synthesis of glutathione. As part of the larger antioxidant system GSH2 ensures cells are protected from damage caused by reactive oxygen species.

Pathways

The glutathione synthesis pathway relies heavily on GSH2's activity influencing the glutathione metabolism pathway. This pathway is critical for antioxidant defense and various metabolic processes. GSH2 closely interacts with enzymes like glutathione reductase and glutathione peroxidase emphasizing its importance in maintaining cellular homeostasis.

GSH2 mutations or dysregulation can lead to conditions such as glutathione synthetase deficiency and oxidative stress-related disorders. These conditions often involve impaired glutathione metabolism linking GSH2 to neurological and metabolic dysfunctions. GSH2 mutations affect proteins like catalase and superoxide dismutase resulting in reduced efficiency in combating oxidative stress.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed : 31412107). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (By similarity).
See full target information GSX2
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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