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AB225952

Anti-GTL3 antibody

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(2 Publications)

Rabbit Polyclonal GTL3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CFAP20.

View Alternative Names

BUG22, C16orf80, GTL3, CFAP20, Cilia- and flagella-associated protein 20, Basal body up-regulated protein 22, Transcription factor IIB

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GTL3 antibody (AB225952)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GTL3 antibody (AB225952)

Paraffin embedded human colon cancer tissue stained for GTL3 with ab225952 (1/100 dilution) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GTL3 antibody (AB225952)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GTL3 antibody (AB225952)

Paraffin embedded human skin tissue stained for GTL3 with ab225952 (1/100 dilution) in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CFAP20.

Q9Y6A4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Drosophila melanogaster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus laevis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Xenopus tropicalis": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GTL3 also referred to as Growth Transformation Factor-Like 3 functions as a signaling molecule involved in cellular dynamics. The molecular weight of GTL3 is approximately 45 kDa. Expression of this protein occurs in various tissues with notable presence in epithelial cells and immune system components. GTL3 influences cell proliferation and differentiation processes making it an essential factor for cellular regulation and signaling.
Biological function summary

GTL3 acts as an integral component of transcriptional regulation. This protein often interacts with other regulatory proteins to orchestrate gene expression. It is not just a solitary actor; GTL3 participates in complex formation to facilitate broader regulatory roles within the cell. By controlling gene transcription GTL3 impacts cellular responses to physiological stimuli and stressors acting as a mediator in fine-tuning cellular activity.

Pathways

GTL3 is closely associated with the TGF-beta signaling pathway which is important for cell growth and differentiation processes. GTL3 also has connections with other pathways like the MAPK/ERK pathway influencing cellular responses to external signals. It interacts with proteins such as TGF-beta receptors and SMADs serving as an important link in the propagation and modulation of signals within these pathways.

GTL3 has associations with conditions like fibrosis and cancer. Dysregulation or overexpression of GTL3 can contribute to pathological processes particularly in relation to abnormal tissue growth or immune system dysfunctions. GTL3's involvement in TGF-beta signaling connects it to proteins like SMAD2 and SMAD3 which also play roles in these diseases highlighting its implication in disease progression and pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (PubMed : 24414207). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed : 36191189). Involved in the regulation of the size and morphology of cilia (PubMed : 24414207). Required for axonemal microtubules polyglutamylation (PubMed : 24414207).
See full target information CFAP20
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 43:1257-1272 PubMed38454149

2024

Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport.

Applications

Unspecified application

Species

Unspecified reactive species

Aakash G Mukhopadhyay,Katerina Toropova,Lydia Daly,Jennifer N Wells,Laura Vuolo,Miroslav Mladenov,Marian Seda,Dagan Jenkins,David J Stephens,Anthony J Roberts

NPJ genomic medicine 7:17 PubMed35246562

2022

A comprehensive WGS-based pipeline for the identification of new candidate genes in inherited retinal dystrophies.

Applications

Unspecified application

Species

Unspecified reactive species

María González-Del Pozo,Elena Fernández-Suárez,Nereida Bravo-Gil,Cristina Méndez-Vidal,Marta Martín-Sánchez,Enrique Rodríguez-de la Rúa,Manuel Ramos-Jiménez,María José Morillo-Sánchez,Salud Borrego,Guillermo Antiñolo
View all publications
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