AB36905

Anti-H Cadherin antibody

Name: Anti-H Cadherin antibody (ab36905) | Abcam
Brand: Abcam Limited
SKU: AB36905
Price: 670 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(4 Publications)

Rabbit Polyclonal H Cadherin antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CDH13 aa 150-200.

View Alternative Names

CDHH, CDH13, Cadherin-13, Heart cadherin, P105, Truncated cadherin, H-cadherin, T-cad, T-cadherin

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody (AB36905)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody (AB36905)

Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse brain tissue labeling H Cadherin with Anti-H Cadherin antibody (ab36905) at 5μg/ml.

Supplier Data

Western blot - Anti-H Cadherin antibody (AB36905)

Lane 1:

Western blot - Anti-H Cadherin antibody (ab36905) at 0.5 µg/mL

Lane 2:

Western blot - Anti-H Cadherin antibody (ab36905) at 1 µg/mL

All lanes:

3T3 cell lysate.

Predicted band size: 78 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human CDH13 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

P55290

Specificity

This antibody is specific for H Cadherin.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

H Cadherin also known as Cadherin-13 or T-cadherin is a unique member of the cadherin family of cell adhesion molecules. It weighs approximately 95 kDa. Unlike classical cadherins H Cadherin lacks the transmembrane and cytoplasmic domains anchoring instead to the membrane via a glycosylphosphatidylinositol (GPI) anchor. H Cadherin expresses in various tissues including endothelial cells cardiac muscle and neurons suggesting its versatile role in different biological contexts.

Biological function summary

The protein plays a role in cell-cell interactions and tissue organization without forming typical adherens junctions. Researchers have identified H Cadherin as a part of the significant complex involved in neural network formation vascular patterning and cardiac tissue integrity. In neurons its expression modulates axon growth and guidance. In the cardiovascular system it contributes to heart function and blood vessel maintenance through its adhesive properties and involvement in signaling pathways.

Pathways

Several biological networks incorporate H Cadherin as an important element. Notably it participates in the Wnt signaling and PI3K/AKT pathways. H Cadherin interacts with proteins such as β-catenin in the Wnt pathway influencing cellular responses like proliferation and differentiation. In the PI3K/AKT pathway the protein may affect cell survival and metabolism. These interactions illustrate H Cadherin's involvement in important cellular processes.

H Cadherin has significant associations with cardiovascular diseases and certain cancers. Altered expression levels or mutations in H Cadherin can disrupt cellular adhesion and signaling contributing to the progression of atherosclerosis and tumor formation. In cancer linkages between H Cadherin and other cadherin family members like E-cadherin suggest complex interactions that can modulate tumor cell behavior influencing invasion and metastasis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

See full target information CDH13

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancers 16: PubMed38791932

2024

The Role of T-Cadherin (CDH13) in Treatment Options with Garcinol in Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Sebastian Staebler,Sebastian Hoechst,Aranya Thongmao,Nadja Schneider,Anja-Katrin Bosserhoff,Silke Kuphal

Journal of oncology 2020:7262479 PubMed32411241

2020

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Luigi Sapio,Ersilia Nigro,Angela Ragone,Alessia Salzillo,Michela Illiano,Annamaria Spina,Rita Polito,Aurora Daniele,Silvio Naviglio

Cell biochemistry and biophysics 70:491-7 PubMed24888493

2014

Down-regulation of adiponectin receptors in osteoarthritic chondrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Qiang Wang,Jun Cai,Jingcheng Wang,Chuanzhi Xiong,Lianqi Yan,Zhiqiang Zhang,Yongchao Fang,Jianning Zhao

Pigment cell & melanoma research 22:296-306 PubMed19368692

2009

H-cadherin expression reduces invasion of malignant melanoma.

Applications

WB, ICC/IF

Species

Human, Human

Silke Kuphal,Adam C Martyn,Julie Pedley,Lisa M Crowther,Vanessa F Bonazzi,Peter G Parsons,Anja K Bosserhoff,Nicholas K Hayward,Glen M Boyle

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-H Cadherin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody (AB36905)

Western blot - Anti-H Cadherin antibody (AB36905)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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