JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB188978

Anti-H4R antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal H4R antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HRH4.

View Alternative Names

GPCR105, HRH4, Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H4R antibody (AB188978)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H4R antibody (AB188978)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lymph node tissue labeling H4R with ab188978 at 24 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human HRH4. The exact immunogen used to generate this antibody is proprietary information.

Q9H3N8

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "12-24 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: 99% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The histamine H4 receptor (H4R) functions mechanically as a G protein-coupled receptor (GPCR). It binds to histamine a regulatory biogenic amine involved in immune response. Its molecular mass is approximately 44 kDa. H4R exhibits expression mainly in bone marrow thymus spleen and other immune-related tissues. Researchers sometimes refer to it as HH4R.
Biological function summary

The H4 receptor plays a significant role in the regulation of immune cell chemotaxis and cytokine release following histamine activation. It does not form part of a larger receptor complex yet it is instrumental in immune system modulation. Its activity affects the migration of eosinophils and mast cells influencing inflammatory responses.

Pathways

The histamine H4 receptor is highly involved in the histamine signaling pathway and the immune response pathway. These pathways modulate various physiological functions and responses to allergens. Within these pathways H4R interacts with proteins such as the histamine H1 and H2 receptors which also mediate histamine-related responses across different tissues.

The H4 receptor has connections to conditions like allergic rhinitis and asthma. Its role in immune cell recruitment and activation intimates a link to these inflammatory disorders. In these conditions H4R works alongside histamine H1 receptor both contributing to the severity and progression of allergic responses. Researchers explore the receptor as a potential therapeutic target for these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
See full target information HRH4
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Mucosal immunology 11:861-870 PubMed29363669

2018

Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis.

Applications

Unspecified application

Species

Unspecified reactive species

J B Wechsler,A Szabo,C L Hsu,R A Krier-Burris,H A Schroeder,M Y Wang,R G Carter,T E Velez,L M Aguiniga,J B Brown,M L Miller,B K Wershil,T A Barrett,P J Bryce
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB97487

Anti-H4R antibody

primary-antibodies

h4r-antibody-ab97487

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com