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AB113716

Anti-HAAO antibody

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(1 Publication)

Rabbit Polyclonal HAAO antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human HAAO conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, 3-HAO, h3HAO, HAD, HAAO

2 Images
Western blot - Anti-HAAO antibody (AB113716)
  • WB

Unknown

Western blot - Anti-HAAO antibody (AB113716)

All lanes:

Western blot - Anti-HAAO antibody (ab113716) at 1 µg/mL

All lanes:

Mouse liver tissue lysate

Predicted band size: 32 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HAAO antibody (AB113716)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HAAO antibody (AB113716)

Immunohistochemical staining of Formalin-Fixed, Paraffin-Embedded Human Liver using ab113716 at 5μg/ml

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human HAAO conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P46952

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The 3-Hydroxyanthranilate 34-dioxygenase commonly known as HAAO is an enzyme with a molecular mass of around 33 kDa. This enzyme catalyzes the conversion of 3-hydroxyanthranilate to quinolinic acid an important step in the kynurenine pathway of tryptophan metabolism. HAAO expresses strongly in the liver and kidneys with moderate expression in the brain. It is also detected in various other tissues to a lesser extent reflecting its versatile role in different physiological contexts.
Biological function summary

This enzyme plays critical roles in tryptophan catabolism linking amino acid metabolism to several critical biological processes. HAAO's activity produces quinolinic acid which is an intermediate that can further convert into NAD+. Although not part of a larger complex HAAO's function in producing quinolinic acid is important for cellular energy metabolism as NAD+ is a cofactor in redox reactions essential for maintaining energy balance in cells.

Pathways

HAAO operates predominantly within the kynurenine pathway an important route of tryptophan degradation. It connects with enzymes like kynureninase and kynurenine 3-monooxygenase which provide substrates or interact within the same pathway. This pathway not only regulates NAD+ biosynthesis but can influence neuroactive metabolites production implicating HAAO in both metabolic and neurological processes.

Alterations in HAAO activity link to certain neurodegenerative diseases including Alzheimer's disease and Huntington's disease. Elevated quinolinic acid levels a product of HAAO activity can lead to neurotoxicity and have been implicated in these conditions. Additionally studies hint at potential associations with other proteins such as IDO1 and TDO2 which could influence or modulate tryptophan metabolism and therefore affect disease processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
See full target information HAAO
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 12:10505-10519 PubMed33122949

2020

Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Shicheng Liu,Miao Wu,Mengyin Peng
View all publications
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