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AB232778

Anti-HABP2 antibody

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(1 Publication)

Rabbit Polyclonal HABP2 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HABP2.

View Alternative Names

HGFAL, PHBP, HABP2, Hyaluronan-binding protein 2, Factor VII-activating protease, Factor seven-activating protease, Hepatocyte growth factor activator-like protein, Plasma hyaluronan-binding protein, FSAP

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HABP2 antibody (AB232778)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HABP2 antibody (AB232778)

Formalin-fixed, paraffin-embedded human rectum tissue stained for HABP2 using ab232778 at 20μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-HABP2 antibody (AB232778)
  • WB

Supplier Data

Western blot - Anti-HABP2 antibody (AB232778)

All lanes:

Western blot - Anti-HABP2 antibody (ab232778) at 2 µg/mL

All lanes:

Recombinant human HABP2 protein.

Predicted band size: 63 kDa

false

Western blot - Anti-HABP2 antibody (AB232778)
  • WB

Supplier Data

Western blot - Anti-HABP2 antibody (AB232778)

All lanes:

Western blot - Anti-HABP2 antibody (ab232778) at 1 µg/mL

Lane 1:

Pig kidney tissue lysate

Lane 2:

Pig intestine tissue lysate

Lane 3:

Pig liver tissue lysate

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/1000 dilution

Predicted band size: 63 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human HABP2.

Q14520

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab232778 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Hyaluronan-Binding Protein 2 (HABP2) also known as Factor VII activating protease is a serine protease with an approximate mass of 65 kDa. This protein gets expressed mainly in the liver and secreted into the bloodstream. HABP2 participates in extracellular matrix interactions by binding to hyaluronan. It plays a role in coagulation processes. The protein also influences angiogenesis highlighting its mechanical involvement in vascular biology.
Biological function summary

HABP2 functions as a regulator in the maintenance of blood homeostasis and tissue remodeling. It takes part in fibrinolysis the process that prevents blood clots from growing and becoming problematic. HABP2 works together with fibrin to facilitate clot breakdown. It may also interact with plasminogen activators within these complexes to accomplish its biological functions effectively.

Pathways

HABP2 integrates into the fibrinolytic and coagulation pathways. It contributes to ensuring that the balance between clot formation and breakdown is maintained. The protein shows interactions with other components like urokinase-type plasminogen activator (uPA) which also plays a role in fibrinolysis. This highlights HABP2's participation in processes that involve preventing thrombosis.

HABP2 has associations with cardiovascular disorders including venous thromboembolism. Aberrant activity of HABP2 may contribute to an increased risk of thrombosis. The protein's interaction with plasminogen and fibrin suggests its involvement in abnormal clotting disorders. Further study into HABP2's role could aid in understanding its potential as a therapeutic target in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed : 10754382, PubMed : 11217080, PubMed : 8827452). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed : 26222560).
See full target information HABP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 14:4310-4320 PubMed35836868

2022

Follistatin-like 1 ameliorates severe acute pancreatitis associated lung injury via inhibiting the activation of NLRP3 inflammasome and NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liming Wang,Na Wang,Guifang Shi,Shuqing Sun
View all publications
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Product promise

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