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AB197395

Anti-hair cortex Cytokeratin/K40 antibody

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(1 Publication)

Rabbit Polyclonal hair cortex Cytokeratin/K40 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT40.

View Alternative Names

KA36, KRT40, Cytokeratin-40, Keratin-40, Type I hair keratin Ka36, CK-40, K40

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hair cortex Cytokeratin/K40 antibody (AB197395)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hair cortex Cytokeratin/K40 antibody (AB197395)

Immunohistochemical analysis of formalin fixed paraffin embedded human cervical cancer tissue, labeling hair cortex Cytokeratin/K40 with ab197395 at a 1/50 dilution.

Western blot - Anti-hair cortex Cytokeratin/K40 antibody (AB197395)
  • WB

Supplier Data

Western blot - Anti-hair cortex Cytokeratin/K40 antibody (AB197395)

8% SDS PAGE gel

All lanes:

Western blot - Anti-hair cortex Cytokeratin/K40 antibody (ab197395) at 1/950 dilution

All lanes:

LOVO cell lysate at 40 µg

Predicted band size: 48 kDa

false

Exposure time: 10s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human KRT40. The exact immunogen used to generate this antibody is proprietary information.

Q6A162

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Alternative Products

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AB16113

Anti-hair cortex Cytokeratin/K40 antibody [AE13]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hair cortex Cytokeratin also known as K40 is a type of intermediate filament protein with a molecular mass of approximately 40 kDa. It is an important structural component in the hair shaft particularly within the cortex where it contributes to the mechanical properties of hair fiber. K40 is predominantly expressed in keratinocytes found in the hair follicle's inner layers including the scalp. This protein provides toughness and elasticity to the hair and it plays a significant role in maintaining hair integrity.
Biological function summary

Cytokeratin K40 helps form a stable cytoskeletal network that supports the structural framework of the hair shaft. Within the keratin family K40 is part of a larger complex of keratin proteins that interact to form strong fibrous structures. It partners with other keratins like AE13 to reinforce the mechanical durability of hair. This complex network supports the rigidity and resilience necessary to resist environmental damage and mechanical stress.

Pathways

The function of hair cortex Cytokeratin K40 interweaves with processes involved in epithelial cell differentiation and hair formation. K40 aligns with the keratinization pathway where it collaborates with related keratins to implement the transformation of keratinocytes into the keratin-rich hair cortex. This pathway connects K40 with proteins like AE1 and AE13 which together facilitate the assembly of a robust cytoskeletal matrix essential for forming healthy hair.

Alterations in Cytokeratin K40 expression can relate to hair shaft disorders and conditions like alopecia. These diseases often arise when the normal architecture and strength of hair fibers are compromised. Within this context changes in K40 may also impact the activity of other keratin proteins such as b and AE13 exacerbating the severity of hair brittleness and growth issues. Understanding the role of K40 may help develop therapeutic strategies to manage or treat associated hair disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in late hair differentiation.
See full target information KRT40
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Life metabolism 1:242-257 PubMed39872077

2022

A multi-omic landscape of steatosis-to-NASH progression.

Applications

Unspecified application

Species

Unspecified reactive species

Liping Xiang,Xiaoyan Li,Yunchen Luo,Bing Zhou,Yuejun Liu,Yao Li,Duojiao Wu,Lijing Jia,Pei-Wu Zhu,Ming-Hua Zheng,Hua Wang,Yan Lu
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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